Bactericidal Action of 4,4'-(α, ω-Polymethylenedithio)bis-(1-alkylpyridinium iodide)s
スポンサーリンク
概要
- 論文の詳細を見る
Bactericidal action of novel bis-quaternay ammonium compounds (bis-QACs), 4,4'-(α, ω-polymethylenedithio)bis(1-alkylpyridinium iodide)s (4DTBP-m, n) was studied. The bactericidal activity of 4DTBP-m, n in water was not affected by the molecular hydrophobicity unlike general mono-QAC, N-dodecylpyridinium iodide (P-12), while the bacteriostatic activity in the medium was reduced with their hydrophobicity. This result suggested that the hydrophobic materials in the medium interact with 4DTBP-m, n and cover their active moiety. Since the bactericidal activity using the measurement system supplemented with peptone was influenced by the molecular hydrophobicity, this speculation was supported. The plots of the bacteriostatic activities of 4DTBP-m, n against the surface hydrophobicities of various bacteria accord to the straight line as in the case of P-12. The slope of the line of 4DTBP-6,12 was comparatively smaller than that of 4DTBP-6,8,indicating that the compounds having longer alkyl group tend to reduce their activities against the bacteria with hydrophobic cell surface because of their interaction with the hydrophobic materials. The novel bis-QACs have an ability to liberate rapidly and abundantly the turbid materials from cells, that is, a bacterioclastic activity. The bacterioclastic activity of P-n was influenced by the length of alkyl group, while 4DTBP-6,n had almost the same activity regardless of its length. Observation by scanning electron microscope (SEM) revealed that 4DTBP-6,8 fatally damaged Escherichia coli cells, and that the morphological alteration of the cells caused by the bis-QAC was greatly different from that of the usual QAC. Therefore, the effective bacterioclastic action, and excellent bactericidal action is due to the unique dimeric structure of 4DTBP-m, n.
- 公益社団法人日本薬学会の論文
- 1998-10-15
著者
-
MAEDA Takuya
Department of Tropical Medicine and Parasitology, School of Medicine, Keio University
-
Maeda Takuya
Department Of Biotechnology Faculty Of Eigineering Osaka University
-
Maeda Takuya
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
-
Ohkura Kazuto
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
-
Ohkura Kazuto
Department Of Applied Biological Sciences School Of Agricultural Sciences Nagoya University
-
Ohno Kosei
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
NAGAMUNE Hideaki
Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
-
KOURAI Hiroki
Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
-
OKAZAKI KIYO
Faculty of Human Life Science, Shikoku University
-
Okazaki K
Faculty Of Human Life Science Shikoku University
-
Kourai Hiroki
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
-
Manabe Y
Department Of Oral Microbiology School Of Dentistry The University Of Tokushima
-
MANABE Yuki
Department of Chemical Science and Technolgy, Faculty of Engineering, The University of Tokushima
-
Nagamune Hideaki
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
-
Manabe Yuki
Department of Applied Physics, Tohoku University, Sendai 980-8579, Japan
-
Maeda Takuya
Department of Agricultural Chemistry, University of Osaka Prefecture
-
Kourai Hiroki
Department of Applied Chemistry, Technical College of Tokushima University
関連論文
- Effect of Extracellular Calcium on the Intracellular Calcium Level of Newborn Rat Skin Basal Cells
- Control of Cell Growth Rate by Sugar Feeding Based on CO_2 Production Rate
- Production of S-(+)-Ibuprofen with High Optical Purity from a Nitrile Compound by Cells immobilized on Cellulose Porous Beads
- Production of S-(+)-Ibuprofen from a Nitrile Compound by Enzymatic Reaction Combined with Ultrafiltration
- Bacterial Alginate Lyase : Enzymology, Genetics and Application
- Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast
- Stimulation of Insulin Action and Stabilization of Cell Membrane in 3T3-L1 Cells by Glycinin Acidic Subunit A_
- Effect of Culture Matrix on Newborn Rat Skin Basal Cells; Modification of Cell Response to Extracellular Calcium
- Effects of Biscoclaurine Alkaloid Cepharanthine on Newborn Rat Skin Epidermal and Dermal Cells
- Flavonoids from Trachelospermum jasminoides
- Minor Flavonoids from Trachelospermum jasminoides var. pubescens
- Comparison of Antioxidative Activity of Phenolic Compounds in Boreava orientalis and Their Related Compound
- Production of Bacterial Alginate-Specific Lyase by Recombinant Bacillus subtilis
- Crystallization and Preliminary X-Ray Diffraction Studies of Bacterial Alginate Lyase
- Metabolic Flux Change in Hybridoma Cells under High Osmotic Pressure
- 524 Improvement of Monoclonal Antibody Production with Gradual Increase of Osmotic Pressure
- Effect of Insoluble Medium Component on the Productivity of Tissue Plasminogen Activator by Cells on Microcarriers
- An Oxygen Supply Strategy for the Large-Scale Production of Tissue Plasminogen Activator by Microcarrier Cell Culture
- Stereoselective Synthesis of Tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones from 5-Fluoro-1,3-dimethyluracil and Naphthalenes
- Acid-Catalyzed Photoreaction of 6-Chloro-1, 3-Dimethyluracil and Mesitylene : Formation of Photocycloadducts and Their Characterization^
- The Human-Specific Action of Intermedilysin, a Homolog of Streptolysin O, Is Dictated by Domain 4 of the Protein
- Synthesis and Biological Properties of Gemini Quaternary Ammonium Compounds, 5,5'-[2,2'-(α,ω-Polymethylnedicarbonyldioxy)diethyl]bis-(3-alkyl-4-methylthiazolium iodide) and 5,5'-[2,2'-(p-Phenylenedicarbonyldioxy)diethyl]bis(3-alkyl-4-methylthiazolium brom
- Antifungal Characteristics of N,N'-Hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide)
- Synthesis of 4, 4'-(Tetramethylenedicarbonyldiamino)-bis(1-decylpyridinium bromide) and Its Antimicrobial and Deodorant Characteristics
- Synthesis and Antimicrobial Characteristics of N, N'-Hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide
- Synthesis and Antimicrobial Characteristics of 5, 5'-[2, 2'-(Tetramethylenedicarbonyldioxy) diethyl] bis(3-alkyl-4-methylthiazolium iodide)s
- Synthesis and Antimicrobial Characteristics of Novel Biocides, 4,4'-(1,6-Hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s
- Synthesis and Bactericidal Characteristics of N-Alkyl-2-benzylaminopyridinium Iodides
- A case of post-malaria neurological syndrome (PMNS) after treatment of falciparum malaria with artesunate and mefloquine
- Synthesis of N1,N1-Free Pyrimidine Bridged Polycyclic Compounds via Photo-Diels-Alder Reaction of N,N-Diacetyl-5-fluorouracil with Naphthalenes
- Response of Bacillus subtilis and Klebsiella pneumoniae to High Pressure
- Rational Design for Stabilization and Optimum pH Shift of Serine Protease AprN
- Nucleotide Sequence and Possible Functional Mechanism of the Transcriptional Activator Gene (preL) for Neutral Protease from Lactobacillus sp.
- Nucleotide Sequence of the Neutral Protease Gene (nprL) from Lactobacillus sp. and Characterization of the Enzyme
- Purification and Characterization of a New Metal Protease Which Hydrolyzes the Cyclic Decapeptide, Gramicidin S
- Cloning and Nucleotide Sequence of the Regulatory Gene, degM, for Minor Serine Protease in Baciilus subtilis
- Role of the Pre-Pro-Region of Neutral Protease in Secretion in Bacillus subtilis
- Molecular basis of group A streptococcal pyrogenic exotoxin B
- Antibacterial Activity and Characteristics of Modified Ferrite Powder Coated with a Gemini Pyridinium Salt Molecule
- Correlation between the Bacterioclastic Action of a Bis-quaternary Ammonium Compound and Outer Membrane Proteins
- Construction of a Leftover Bath Water Model for Microbial Testing
- Characterization and Protein Analysis of Escherichia coli Resistant to a Quaternary Ammonium Compound
- Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by Streptococcus intermedius
- Synthesis and Antimicrobial Characteristics of a Novel Biocide, 4, 4'-(1, 6-Dioxyhexamethylene)bis-(1-alkylpyridinium halide)
- Synthesis and Antimicrobial Characteristics of Novel Biocides, 1, 1'-(Decanedioyl)bis(4-methyl-4-alkylpiperazinium iodide)s with a Gemini Structure
- Synthesis and Antimicrobial Characteristics of Novel Antimicrobial Agent, 1,4-Dialky-1,4-dihydroxyethylpiperadinium Diiodides Immobilized on Inorganic Materials
- Antimicrobial Characteristics of Bis-quaternary Ammonium Compounds Possessing a p-Phenylene Group in Their Spacer Chains
- Kinetic Analysis of the Bactericidal Action of a Bis-quaternary Ammonium Compound against Escherichia coli
- Bactericidal Action of a Bis-puaternary Ammonium Compound against Vegetative Cells and Spores of Bacillus subtilis
- Characterization of Pseudomonas aeruginosa Resistant to a Quaternary Ammonium Compound
- Synthesis and Antimicrobial Characteristics of 4,4',4''-(1,2,3-Propylenetrithio)tris-(1-alkylpyridinium iodide)s
- Control of Legionella Species and Host Amoeba by Bis-quaternary Ammonium Compounds
- Purification and Characterization of a Novel Serine Proteinase from the Microsomal Fraction of Bovine Pancreas^1
- Bactericidal Action of 4,4'-(α, ω-Polymethylenedithio)bis-(1-alkylpyridinium iodide)s
- Synthesis and Antimicrobial Characteristics of 4,4'-(α, ω-Polymethylenedithio)bis(1-alkylpyridinium iodide)s
- Synthesis and Antibacterial Characteristics of N-Alkyl-4-Allylthiopyridinium Bromides
- Quantitative Structure-Activity Relationship of Antibacterial Dodecylpyridinium lodide Derivatives
- Bactericidal Action of N-Alkylcyanopyridinium Bromides against Escherichia coli K12 W3110
- The Properties of Bacterial Adaptation to Mono- and Bis-Quaternary Ammonium Compounds
- Microbial Contamination in Home Laundry Operations in Japan
- Visible Light-Induced Bactericidal Species Generated From Silver-Loaded Hydrogen Zirconium Phosphate Active Against Escherichia coli K12
- Acid-catalyzed Photorearrangement of the Bond-switching Isomer of a Pentamethylcyclooctapyrimidine-2,4-dione
- Photochemical Synthesis and Characterization of the Tautomers of 1,3,4,7,9- and 1,3,6,8,10-Pentamethylcyclooctapyrimidine-2,4-diones
- Background and Evidence Leading to the Establishment of the JIS Standard for Antimicrobial Products
- A Novel Human PACE4 Isoform, PACE4E Is an Active Processing Protease Containing a Hydrophobic Cluster at the Carboxy Terminus^1
- Cloning and Sequence Analysis of a Plasmid-encoded 2-Haloacid Dehalogenase Gene from Pseudomonas putida No. 109
- The Mode of the Antifungal Activity of Gemini-Pyridinium Salt against Yeast
- Pathogenic Bacteria Carried by Companion Animals and Their Susceptibility to Antibacterial Agents
- Flavonoids from Trachelospermum jasminoides(Natural Medicine Note)
- Minor Flavonoids from Trachelospermum jasminoides var. pubescens(Natural Medicine Note)
- Sialidase of Streptococcus intermedius : a putative virulence factor modifying sugar chains
- Analysis of DWI ASPECTS and Recanalization Outcomes of Patients with Acute-phase Cerebral Infarction
- Organosoluble Oligomer Obtained by Glycolysis of Poly (ethylene terephthalate) and Its Detailed Structural Characterization by MALDI-TOF Mass Spectrometry
- Microbial Contamination in Home Laundry Operations in Japan
- The Properties of Bacterial Adaptation to Mono- and Bis-Quaternary Ammonium Compounds
- Bacterioclastic Action of a Bis-Quaternary Ammonium Compound against Escherichia coli
- Bactericidal Action of a Bis-puaternary Ammonium Compound against Vegetative Cells and Spores of Bacillus subtilis
- Action of Reactive Oxygen Species in the Antifungal Mechanism of Gemini-pyridinium Salts Against Yeast
- Synthesis of 4, 4'-(Tetramethylenedicarbonyldiamino)-bis(1-decylpyridinium bromide) and Its Antimicrobial and Deodorant Characteristics
- Development of a Code Clone Search Tool for Open Source Repositories
- Cell Sorting Model Based on Cell Signaling
- Small heat shock protein AgsA : An effective stabilizer of enzyme activities(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- First Principles Calculation of Magnetocrystalline Anisotropy Energy of MnBi and MnBi
- Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex
- Studies of the selective O-alkylation and dealkylation of flavonoids. V. The synthesis of 5,6-dihydroxy-3,4',8-trimethoxyflavone and a revised structure for the flavone from Conyza stricta.
- Studies of the selective O-alkylation and dealkylation of flavonoids. VI. Demethylation of 8-hydroxy-5,7-dimethoxyflavones with anhydrous aluminum chloride or bromide in acetonitrile.
- Small heat shock protein AgsA : An effective stabilizer of enzyme activities