Effect of Extracellular Calcium on the Intracellular Calcium Level of Newborn Rat Skin Basal Cells

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概要

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• The effect of extracellular calcium on the intracellular calcium level of newborn rat skin basal cells was examined. The intracellular calcium level of basal cells was affected by the extracellular calcium concentration on culture of the cells on a collagen-coated filter, but not on a plate. The intracellular calcium ion concentration ([Ca^<2+>]_i) of cells on a collagen-coated filter with 0.05mM external CaCl_2 was 15nM and increased to 20-22nM on culture with 2.0mM extracellular CaCl_2. From these results we concluded that the culture matrix (e.g. culture plates, or collagen-coated filters) affects the response of the basal cells to changes in the extracellular calcium content.The intracellular calcium level of Swiss 3T3 cells cultured both on plates and collagen-coated filters were affected by the extracellular calcium concentration. Their [Ca^<2+>]_i was determined as 49-50nM in the presence of 0.05mM external CaCl_2,and 54-56nM in the presence of 2.0mM CaCl_2. These different responses to extracellular Ca^<2+> may be due to differences in the proliferative profiles of basal cells and fibroblasts.

• 社団法人日本薬学会の論文
• 1998-01-15

著者

• 堀 均

  Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science

• HORI Hitoshi

  Departmet of Biological Science and Technology, Faculty of Engineering, University of Tokushima

• Hosoi Hiroshi

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• 堀 均

  徳島大学工学部

• OHKURA Kazuto

  Faculty of Pharmaceutical Sciences, University of Tokushima

• TERADA Hiroshi

  Department of Applied Biological Sciences, Faculty of Agricultural Science, Nagoya University

• Ohkura Kazuto

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Ohkura Kazuto

  Department Of Applied Biological Sciences School Of Agricultural Sciences Nagoya University

• Ohno Kosei

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Okazaki K

  Faculty Of Human Life Science Shikoku University

• Hori Hitoshi

  Department Of Biochemistry And Molecular Biology Nippon Medical School

• Terada Hiroshi

  Department Of Applied Biological Sciences Faculty Of Agricultural Science Nagoya University

• Ohkura Kazuto

  Faculty of Human Life Science, Shikoku University

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