Studies of Methyl 2-Nitroimidazole-1-acetohydroxamate (KIN-804) 1 : Effect on Free Radical Scavenging System in Mice Bearing Ehrlish Ascites Carcinoma
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概要
- 論文の詳細を見る
Methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804) is a 2-nitroimidazole derivative containing a hydroxamate side chain designed to enhance the radiosensitization response of hypoxic cells. The possible sensitization of tumor tissue by KIN-804 can be evaluated through investigation of the levels of the free radical scavengers; namely, glutathione (GSH) and its complex enzyme system including glutathione reductase (GR) and glutathione peroxidase (GSH-Px), as well as glucose-6-phosphate dehydrogenase (G-6-PD). Female albino mice were inoculated with Ehrlich carcinoma in the thigh. Administration of KIN-804 (i.p. 80 mg/kg body weight) was carried out 20 min before localized irradiation of 10 Gy. The data revealed that KIN-804 administration, followed or not by gamma irradiation, resulted in a significant decrease in GSH content in tumor tissues associated with inhibition in GR and G-6-PD activities. Blood GSH-Px was enhanced in tumor inoculated mice and the administration of KIN-804 returned it to the normal value. These changes were more noticeable in tumor bearing mice exposed to both KIN-804 and irradiation.
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
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堀 均
Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science
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NAGASAWA Hideko
Departmet of Biological Science and Technology, Faculty of Engineering, University of Tokushima
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UTO Yoshihiro
Departmet of Biological Science and Technology, Faculty of Engineering, University of Tokushima
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HORI Hitoshi
Departmet of Biological Science and Technology, Faculty of Engineering, University of Tokushima
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Hosoi Hiroshi
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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堀 均
徳島大学工学部
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永沢 秀子
岐阜薬科大学創薬化学大薬化学
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Hori Hitoshi
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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ABU-ZEID Medhat
Department of Cancer Biology, National Cancer Institute, Cairo University
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INAYAMA Seiichi
Institute of Oriental Medical Sciences
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稲山 誠一
Institute Of Oriental Medical Sciences
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稲山 誠一
慶應義塾大学医学部薬化学研究所
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Uto Yoshihiro
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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Uto Yoshihiro
Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science
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Abu‐zeid M
Department Of Cancer Biology National Cancer Institute Cairo University
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Nagasawa H
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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Nagasawa Hideko
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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Hori Hitoshi
Department Of Biochemistry And Molecular Biology Nippon Medical School
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Uto Yoshihiro
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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