Development of an in vivo Evaluation System of Antioxidants for their Vascular Protective Activities using the Chick Embryonic Chorioallantoic Membrane
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概要
- 論文の詳細を見る
The drug discovery research of clinical-use antioxidants, which may control various vasculardisorders caused by the oxidative stress, is extremely important. We present the development of anin vivo evaluation system of antioxidants for their vascular protective activities using the chickembryonic chorioallantoic membrane (CAM). In the case of 12-days chick embryos, the topicaladministration of 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) induced theirvascular injuries against the CAM veins and venous capillaries but without substantial fatal damage.Artepillin C, a potent natural antioxidant, did not show the chick embryo’s venous injury, andpre-treatment with artepillin C would tend to protect the CAM veins injuries induced by thepost-administration of AAPH. These results suggest that artepillin C might be able to protect theAAPH-induced vascular injury in in vivo. In conclusion, we showed the possibility of in vivoevaluation system of antioxidants for their vascular protective activities using the chick embryo.
- 徳島大学の論文
著者
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堀 均
Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science
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堀 均
徳島大学 大学院ソシオテクノサイエンス研究部ライフシステム部門
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Hosoi Hiroshi
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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堀 均
徳島大学工学部
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Hori Hitoshi
Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science
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Hori Hitoshi
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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Abe Chiaki
Graduate School Of Advanced Technology And Science The University Of Tokushima
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Nakata Eiji
Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science
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Uto Yoshihiro
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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Uto Yoshihiro
Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science
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