Studies of Methyl 2-Nitroimidazole-1-acetohydroxamate (KIN-804) 2 : Effect on Certain Antioxidant Enzyme Systems in Mice Bearing Ehrlish Ascites Carcinoma

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概要

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• In order to decrease toxicity and/or increase radiosensitizing activity, a new 2-nitroimidazole derivative, methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804), was synthesized to solve the problem of tumor hypoxia. Evaluation of the efficiency of KIN-804 was carried out through studying the antioxidant enzyme system : The superoxide dismutase (SOD), catalase and lipid peroxide levels provide a rough index of the balance between free radical generation and scavenging. Female albino mice were inoculated with Ehrlish ascites carcinoma (EAC) in the thigh. The administration of KIN-804 (i.p. 80 mg/kg body weight) was carried out 20 min before localizad irradiation of 10 Gy. In general, the data revealed that KIN-804 administration, followed or not by gamma irradiation, exerted significant inhibition of SOD and catalase activities accompanied by a significant increase in lipid peroxide level in tumor-bearing mice.

• 公益社団法人日本薬学会の論文
• 2000-02-01

著者

• 堀 均

  Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science

• NAGASAWA Hideko

  Departmet of Biological Science and Technology, Faculty of Engineering, University of Tokushima

• UTO Yoshihiro

  Departmet of Biological Science and Technology, Faculty of Engineering, University of Tokushima

• HORI Hitoshi

  Departmet of Biological Science and Technology, Faculty of Engineering, University of Tokushima

• Hosoi Hiroshi

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• 堀 均

  徳島大学工学部

• 永沢 秀子

  岐阜薬科大学創薬化学大薬化学

• 永沢 秀子

  徳島大学工学部

• Hori Hitoshi

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• ABU-ZEID Medhat

  Department of Cancer Biology, National Cancer Institute, Cairo University

• INAYAMA Seiichi

  Institute of Oriental Medical Sciences

• 稲山 誠一

  Institute Of Oriental Medical Sciences

• 稲山 誠一

  慶應義塾大学医学部薬化学研究所

• Uto Yoshihiro

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Uto Yoshihiro

  Division Of Bioinformatics Engineering Department Of Life System Institute Of Technology And Science

• Abu‐zeid M

  Department Of Cancer Biology National Cancer Institute Cairo University

• Nagasawa H

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Nagasawa Hideko

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Hori Hitoshi

  Department Of Biochemistry And Molecular Biology Nippon Medical School

• Uto Yoshihiro

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

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