THE ABSOLUTE CONFIGURATION AND CONFORMATION OF NEOCURDIONE

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概要

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• The complete stereostructure of neocurdione (1a) from Curcuma wenyujin and C. aromatica was determined unequivocally on the basis of chemical transformation of curdione (2a) to 4-epicurdione (1b) as well as X-ray crystallography of the p__-bromobenzoate (3b) of 8αH-dihydro-4-epicurdione (3a). The preferred conformation of 1__〜a in solution was found to be A [C(10)-CH_3/C(5)=O : anti] based on ^1H-NMR spectromethy at various temperatures, and NOE measurements, especially at -60℃. In contrast, the preferred conformation of 1__〜a in crystals (X-ray) was found to be B__〜 [C(10)-CH_3/C(5)=O : syn]. A conformational analysis of 1__〜a, 1__〜b and 2__〜a is also presented based on molecular dynamics calculations using MM2.

• 公益社団法人日本薬学会の論文
• 1986-10-25

著者

• 大倉 多美子

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Nishi-tokyo Science University

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 福島 清吾

  Shizuoka College of Pharmacy

• 黒柳 正典

  Shizuoka College of Pharmacy

• 稲山 誠一

  Pharmaceutical Institute, School of Medicine, Keio University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 播磨谷 健蔵

  Pharmaceutical Institute, Tohoku University

• 引地 学

  Pharmaceutical Institute, School of Medicine, Keio University

• 川又 健

  Pharmaceutical Institute, School of Medicine, Keio University

• 黒柳 正典

  School Of Pharmaceutical Sciences University Of Shizuoka

• 高 集馥

  Pharmaceutical Institute, School of Medicine, Keio University

• 高 集馥

  Pharmaceutical Institute School Of Medicine Keio University

• 稲山 誠一

  Institute Of Oriental Medical Sciences

• 稲山 誠一

  Pharmaceutical Institute School Of Medicine Keio University

• 稲山 誠一

  慶應義塾大学医学部薬化学研究所

• 播磨谷 健蔵

  Pharmaceutical Institute School Of Medicine Keio University

• 川又 健

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 引地 学

  Pharmaceutical Institute School Of Medicine Keio University

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