Effects of Biscoclaurine Alkaloid Cepharanthine on Newborn Rat Skin Epidermal and Dermal Cells
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概要
- 論文の詳細を見る
Effects of biscoclaurine alkaloid cepharanthine on proliferation of skin cells were examined in vitro. The alkaloid was found to enhance attachment and cell layer formation of newborn rat skin epidermal cells in culture on type I collagen-coated Millipore filter, and to potentiate production of keratins in these cells. Spreading and growth of skin dermal fibroblasts were inhibited by cepharanthine in a dose-dependent manner, but the alkaloid-treated cells still retained the ability to synthesize type IV collagen. In culture of skin cells containing both epidermal and dermal cells, no growth of epidermal cells or over-growth of dermal fibroblasts was observed in medium without cepharanthine. In contrast, the presence of the alkaloid suppressed the growth of firoblasts and promoted the formation of epidermal cell layers accompanied by production of keratins. Thus, in comparison with the cells untreated with the alkaloid, cepharanthine-treated skin epidermal and dermal cells in vitro expressed in vivo-like characters.
- 社団法人日本薬学会の論文
- 1996-04-15
著者
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Terada H
Nagoya Univ. Nagoya Jpn
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URAKAMI Kenji
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni
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MAKINO Shio
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni
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Makino S
Nagoya Univ. Nagoya Jpn
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Makino Shio
Department Of Applied Biological Science Faculty Of Agriculture Nagoya University
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Urakami Kenji
Department Of Applied Biological Sciences School Of Agricultural Sciences Nagoya University
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TERADA Hiroshi
Faculty of Pharmaceutical Sciences, University of Tokushima
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Ohkura Kazuto
Department of Applied Biological Sciences, Faculty of Agricultural Science, Nagoya University
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Ohkura Kazuto
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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Ohkura Kazuto
Department Of Applied Biological Sciences School Of Agricultural Sciences Nagoya University
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Ohkura Kazuto
Department Of Applied Biological Sciences Faculty Of Agricultural Sciences Nagoya University
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Makino S
Nagoya Univ. Aichi Jpn
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Ohno Kosei
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Terada Hiroshi
Faculty Of Pharmaceutical Sciences Tokyo Univ Of Science
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Okazaki K
Faculty Of Human Life Science Shikoku University
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Terada Hiroshi
Faculcv Of Pharmaceutical Sciences Tokyo University Of Science
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寺田 弘
Fac. Of Pharmaceutical Sciences Tokyo Univ. Of Sci.
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