The Gene Encoding Muscle-Type Carnitine Palmitoyltransferase I: Comparison of the 5'-Upstream Region of Human and Rodent Genes

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概要

• 論文の詳細を見る

• Muscle-type carnitine palmitoyltransferase I (M-CPTI) is the key enzyme for fatty acid β-oxidation in heart and skeletal muscles and in adipose tissue. So far, M-CPTI mRNA has been detected in white adipocytes from epididymal fat pads of rats and humans, but not in mouse adipocytes. To characterize the gene expression of M-CPTI in mice, we isolated the genomic DNA encoding mouse M-CPTI and determined its transcription initiation site. As a result, the mouse M-CPTI gene seemed to have multiple initiation sites, as in the case of the rat and human genes. Furthermore, the con-served nucleotide sequence of the response element for peroxisome proliferators was shown to exist in the upstream of the mouse gene as in that of the rat and human genes. From these observations, we suggest that the anomalous expression of M-CPTI in mouse adipocytes reported previously may be regulated by factors other than peroxisome proliferators. Previously, we reported that there were transcripts containing regions of both CK/EK-β and M-CPTI genes in humans. In this study, we found that such transcripts also exist in rodents and that the amounts of the transcripts containing regions of both of these genes did not depend on the expression level of CK/EK-β.

• 社団法人 日本生化学会の論文

著者

• Yamazaki Naoshi

  Faculty Of Pharmaceutical Sciences Univ Of Tokushima

• Terada Hiroshi

  Faculcv Of Pharmaceutical Sciences Tokyo University Of Science

• Hashimoto Yoshiko

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Yamanaka Yasuhisa

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Hiramatsu Takayuki

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Shinohara Yasuo

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• Yamazaki Naoshi

  Faculty of Pharmaceutical Sciences, University of Tokushima

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