Quantitative Estimation of Interaction between Carbohydrates and Concanavalin A by Surface Plasmon Resonance Biosensor

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概要

• 論文の詳細を見る

• We measured the affinity of more than 20 sugars with concanavalin A (ConA) by an optical biosensor (surface plasmon resonance sensor) using asialofetuin (ASF) as an immobilized binding partner of ConA. We determined kinetic parameters of the effects of sugars on the dissociation of ConA from ASF quantitatively, and the structural requirements of the functional groups of sugars for binding with ConA. We found that the affinity of ConA for sugars is dependent on its conformation induced by interaction with the binding partner. In addition, the results showed that optical biosensor system is well mimics the interaction of ConA with sugars in biomembrane.

• 社団法人日本薬学会の論文
• 2002-04-01

著者

• CHUMAN Hiroshi

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• GOTO Satoru

  Faculity of Pharmaceutical Sciences, The University of Tokushima

• Sasaki M

  Faculty Of Engineering Kumamoto University

• Chuman Hiroshi

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Terada H

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Terada H

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• MASUDA Kyoko

  Faculty of Pharmaceutical Sciences, University of Tokushima

• MIURA Miyuki

  Faculty of Pharmaceutical Sciences, University of Tokushima

• KANAZAWA Keiko

  Faculty of Pharmaceutical Sciences, University of Tokushima

• SASAKI Miki

  Faculty of Pharmaceutical Sciences, University of Tokushima

• MASUI Miyuki

  Faculty of Pharmaceutical Sciences, University of Tokushima

• SHIRAMIZU Maki

  Faculty of Pharmaceutical Sciences, University of Tokushima

• TERADA Hiroshi

  Faculty of Pharmaceutical Sciences, University of Tokushima

• Terada Hiroshi

  Faculty Of Pharmaceutical Sciences Tokyo Univ Of Science

• Sasaki M

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Goto Satoru

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Masuda Kyoko

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Miura Miyuki

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Kanazawa K

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Shiramizu Maki

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Masui M

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• Terada Hiroshi

  Faculcv Of Pharmaceutical Sciences Tokyo University Of Science

• Shiramizu M

  Faculty of Pharmaceutical Sciences, University of Tokushima

• Chuman H

  Faculty of Pharmaceutical Sciences, University of Tokushima

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