Cold-Induced Changes in Gene Expression in Brown Adipose Tissue : Implications for the Activation of Thermogenesis
スポンサーリンク
概要
- 論文の詳細を見る
Brown adipose tissue (BAT) is the site of heat production (thermogenesis). This unique function is performed by uncoupling protein 1 (UCP1) specifically expressed in mitochondria of BAT. UCP1 dissipates the driving force of ATP synthesis, and thus causes heat production followed by energy expenditure. The thermogenic function of BAT has the role of maintaining body temperature under cold conditions. When animals are exposed to cold, the expression of UCP1 gene is increased to activate thermogenesis. To date, functional analysis of BAT has been focused on UCP1, because it plays an indispensable role in thermogenesis. However, the gene expression of not only UCP1 but also that of other genes in BAT is expected to be regulated to achieve effective thermogenesis. Our previous investigations showed increased expression of genes that encode several energy metabolic enzymes in the BAT of rats kept in the cold. These changes in gene expression imply that the enhancement of energy metabolism is needed to activate thermogenesis. Furthermore, various reports from studies focused on genes whose expression is changed in response to cold stimulation have provided new insights into the function of BAT. In this review, to understand the thermogenic function of BAT systematically, we have provided an overview of previous findings on changes in the expression of genes thought to be related to the activation of thermogenesis in BAT.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
-
梶本 和昭
北海道大学大学院薬学研究院
-
Kataoka Masatoshi
徳島大学ゲノム機能研究センター遺伝子実験施設
-
Kataoka M
National Institute Of Advanced Industrial Science And Technology
-
Kataoka Masatoshi
Health Technology Research Center National Institute For Advanced Industrial Science And Technology
-
Yamamoto Takenori
Institute for Genome Research
-
Yamazaki Naoshi
Faculty of Pharmaceutical Sciences, Univ of Tokushima
-
Shinohara Yasuo
Institute for Genome Research
-
Shinohara Y
Institute For Genome Research University Of Tokushima:faculty Of Pharmaceutical Sciences University
-
Shinohara Yasuo
Institute For Genome Research University Of Tokushima
-
Shinohara Yasuo
Faculty Of Pharmaceutical Sciences The University Of Tokushima:institute For Genome Research The Uni
-
Ymamoto Takenori
Institute For Genome Research
-
Shinohara Yasuo
Faculty Of Pharmaceutical Sciences University Of Tokushima
-
WATANABE Masahiro
Institute for Genome Research, University of Tokushima
-
MORI Chihiro
Institute for Genome Research, University of Tokushima
-
OKADA Naoto
Institute for Genome Research, University of Tokushima
-
KAJIMOTO Kazuaki
Health Technology Research Center, National Institute for Advanced Industrial Science and Technology
-
Okada Naoto
Institute For Genome Research University Of Tokushima:faculty Of Pharmaceutical Sciences University
-
Mori Chihiro
Institute For Genome Research University Of Tokushima:faculty Of Pharmaceutical Sciences University
-
Yamazaki Naoshi
Faculty Of Pharmaceutical Sciences University Of Tokushima
-
Yamazaki Naoshi
Faculty Of Pharmaceutical Sciences Univ Of Tokushima
-
Kajimoto Kazuaki
Department Of Epidemiology Divisions Of Preventive Medicine
-
Kajimoto Kazuaki
Health Technology Research Center National Institute For Advanced Industrial Science And Technology
-
Kataoka Masatoshi
Department Of Periodontology And Endodontology Tokushima University School Of Dentistry
-
Yamamoto Takenori
Institute For Genome Research University Of Tokushima
-
Watanabe Masahiro
Institute For Genome Research University Of Tokushima:faculty Of Pharmaceutical Sciences University Of Tokushima
-
Yamazaki Naoshi
Faculty of Pharmaceutical Sciences, University of Tokushima
関連論文
- Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues
- Comparison between a Multifunctional Envelope-Type Nano Device and Lipoplex for Delivery to the Liver
- Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue
- イオントフォレシスによる高分子の皮膚透過
- MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion
- Assessment of MEF2A Mutations in Myocardial Infarction in Japanese Patients
- Validation of the Association Between the Gene Encoding 5-Lipoxygenase-Activating Protein and Myocardial Infarction in a Japanese Population
- Effect of Cationic Liposomes in an in Vitro Transcription and Translation System
- Exclusion of the Catechol-O-Methyltransferase Gene from Genes Contributing to Salt-Sensitive Hypertension in Dahl Salt-Sensitive Rats
- Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis
- 2P-225 プロテオミクス解析により明らかにされたミトコンドリア膜の透過性に対するCa^とバリノマイシンの作用の違い(細胞生物学的課題(2),第46回日本生物物理学会年会)
- Three-Way Effect of Cyanine Dye on the Structure and Function of Mitochondria
- High-turnover osteoporosis is induced by cyclosporin A in rats
- Drug-Induced Gingival Overgrowth : a Review
- Regulation of tenascin expression in cultured rat dental pulp cells
- Relationship between the expression of parathyroid hormone receptors and hormonal effect during rat osteoprogenitor cell differentiation
- In Vivo Transdermal Delivery of Diclofenac by Ion-Exchange Iontophoresis with Geraniol(Biopharmacy)
- DNA Microarray Analysis of Whole Blood Cells and Insulin-Sensitive Tissues Reveals the Usefulness of Blood RNA Profiling as a Source of Markers for Predicting Type 2 Diabetes
- Roles of Adjoining Asp and Cys Residues of First Matrix-Facing Loop in Transport Activity of Yeast and Bovine Mitochondrial ADP/ATP Carriers
- Close Location of the First Loop to the Third Loop of the Mitochondrial ADP/ATP Carrier Deduced from Cross-Linking Catalyzed by Copper-o-Phenanthroline of the Solubilized Carrier with Triton X-100
- Significant Expression of Functional Human Type 1 Mitochondrial ADP/ATP Carrier in Yeast Mitochondria
- Irreversible Extrusion of the First Loop Facing the Matrix of the Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling the Cys^ Residue with the SH-Reagent Methyl Methanethiosulfonate^1
- Genome Wide Expression Analysis of White Blood Cells and Liver of Pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Using a cDNA Microarray
- Assessment of Genetic Effects of Polymorphisms in the MCP-1 Gene on Serum MCP-1 Levels and Myocardial Infarction in Japanese
- Evaluation of Cell-free Protein Synthesis Using PDMS-based Microreactor Arrays
- Cold-Induced Changes in Gene Expression in Brown Adipose Tissue : Implications for the Activation of Thermogenesis
- Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue
- miRNA発現解析から分かる褐色脂肪細胞と白色脂肪細胞の分化と起源の相違
- Silver Ion Induces a Cyclosporine A-Insensitive Permeability Transition in Rat Liver Mitochondria and Release of Apoptogenic Cytochrome c
- BIOCHEMICAL AND MICROARRAY ANALYSES OF BUPIVACAINE-INDUCED APOPTOSIS
- The Gene Encoding Muscle-Type Carnitine Palmitoyltransferase I : Comparison of the 5'-Upstream Region of Human and Rodent Genes
- MN-O3 Rapid detection of malaria-infected erythrocytes using a cell microarray chip(Section X Micro/Nano Technology for Analysis and Cell Manipulation)
- Quantitative Comparison of Adipocytokine Gene Expression during Adipocyte Maturation in Non-obese and Obese Rats
- First-Principles Calculation Software for Dielectric Response Study of High-k Materials
- Identification of Muscle-Type Carnitine Palmitoyltransferase I and Characterization of Its Atypical Gene Structure
- Cell penetrating peptide-mediated systemic siRNA delivery to the liver
- A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response
- Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.
- イオントフォレシスによる高分子医藥の皮内送逹
- DDS技術による遺伝子・核酸医薬の将来 (特集 先端医療実用化のための最新DDS技術の動向)
- The gene encoding muscle-type carnitine palmitoyltransferase I: Comparison of the 5 '-upstream region of human and rodent genes
- Silver ion induces a cyclosporine A-insensitive permeability transition in rat liver mitochondria and release of apoptogenic cytochrome C
- Vascular-targeted nanotherapy for obesity: Unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery
- Efficient Intradermal Delivery of Superoxide Dismutase Using a Combination of Liposomes and Iontophoresis for Protection against UV-Induced Skin Damage
- Quantitative Analysis of Serum Procollagen Type I C-Terminal Propeptide by Immunoassay on Microchip
- Ribonuclease protection assay on microchip electrophoresis
- A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication
- Therapeutic Assessment of Cytochrome C for the Prevention of Obesity Through Endothelial Cell-targeted Nanoparticulate System
- The Gene Encoding Muscle-Type Carnitine Palmitoyltransferase I: Comparison of the 5'-Upstream Region of Human and Rodent Genes