Drug-Induced Gingival Overgrowth : a Review
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概要
- 論文の詳細を見る
Drug-induced gingival overgrowth is a side effect associated with 3 types of drugs : anticonvulsants (phenytoin), immunosuppressive agents (cyclosporine A), and various calcium channel blockers for cardiovascular diseases. Gingival overgrowth is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components with various degrees of inflammation. Although the mechanisms of these disorders have not been elucidated, recent studies suggest that these disorders seem to be induced by the disruption of homeostasis of collagen synthesis and degradation in gingival connective tissue, predominantly through the inhibition of collagen phagocytosis of gingival fibroblasts. The integrins are a large family of heterodimeric transmembrane receptors for extracellular matrix molecules. α2β1 integrin serves as a specific receptor for type I collagen on fibroblasts, and α2 integrin has been shown to play a crucial role in collagen phagocytosis. Actin filaments, which are assembled from monomers and oligomers, are involved in collagen internalization after binding to integrins. Furthermore, the implication of intracellular calcium in the regulation of integrin-mediated binding activity and gelsolin activity, known as a calcium-dependent actin-severing protein, is also described. In this review, we focus on collagen metabolism in drug-induced gingival overgrowth, focusing on the regulation of collagen phagocytosis in fibroblasts.
- 社団法人日本薬学会の論文
- 2005-10-01
著者
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Kataoka Masatoshi
徳島大学ゲノム機能研究センター遺伝子実験施設
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Kataoka M
National Institute Of Advanced Industrial Science And Technology
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Kataoka Masatoshi
Health Technology Research Center National Institute For Advanced Industrial Science And Technology
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Nagata Toshihiko
Institute of Health Biosciences
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Nagata Toshihiko
Department of Periodontology and Endodontology, Institute of Health Biosciences, The University of T
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KATAOKA Masatoshi
Division of Gene Expression, Institute for Genome Research, The University of Tokushima
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SHINOHARA Yasuo
Division of Gene Expression, Institute for Genome Research, The University of Tokushima
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KIDO Junichi
Department of Periodontology and Endodontology, Institute of Health Bioscience, The University of To
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Shinohara Y
Institute For Genome Research University Of Tokushima:faculty Of Pharmaceutical Sciences University
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Shinohara Yasuo
Institute For Genome Research University Of Tokushima
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Shinohara Yasuo
Faculty Of Pharmaceutical Sciences The University Of Tokushima:institute For Genome Research The Uni
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Shinohara Yasuo
Faculty Of Pharmaceutical Sciences University Of Tokushima
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Kido Jun-ichi
Department Of Periodontology And Endodontology Institute Of Health Bioscience The University Of Toku
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Nagata T
Department Of Anatomy And Cell Biology Shinshu University School Of Medicine
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Kido Junichi
Department Of Periodontology And Endodontology Institute Of Health Bioscience The University Of Toku
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Nagata Toshihiko
Department Of Periodontology And Endodontology Institute Of Health Bioscience The University Of Toku
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Nagata Toshihiko
Department Of Neuropsychiatry Osaka City University Medical School
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Kataoka Masatoshi
Department Of Periodontology And Endodontology Tokushima University School Of Dentistry
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