Tableting of Coated Particles. II. Influence of Particle Size of Pharmaceutical Additives on Protection of Coating Membrane from Mechanical Damage during Compression Process

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概要

• 論文の詳細を見る

• To compress coated particles into tablets without mechanical damage to the coating membrane during compression, the effect of the particle size of various pharmaceutical additives was investigated by comparing the dissolution rate and the membrane integrity of ethylcellulose coated theophylline powder. Results showed that smaller additive particle size was superior in protecting the membrane from damage, and thus additive particle size might be one of the most omportant factors affecting the dissolution characteristics of compressed tablets containing coated particles. Twenty μm seemed to be the critical particle size for each kind of additive to obtain good protective effect. Up to this size, all additives played the role of cushioning and the coating membrane was almost perfectly protected from potential damage by the compression force.

• 公益社団法人日本薬学会の論文
• 1998-05-15

著者

• Yamada Makiko

  San-ei Gen F.f.i. Inc.

• Yamada M

  Pharmaceutical Research Division Takeda Pharmaceutical Company Limited

• Yao Takashi

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd. :(present Address)production Technology Di

• Yoshida M

  Tohoku Univ. Sendai Jpn

• Yoshida M

  Takamatsu Works Inui Corporation

• YAMADA Misuzu

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• YAMAHARA Hiroshi

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• YOSHIDA Masanori

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• Yamahara H

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.

• Yamahara Hiroshi

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.

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