Optically Active Antifungal Azoles. VIII. Synthesis and Antifungal Activity of 1-[(1R, 2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-substituted phenyl)-2(1H, 3H)-imidazolones and 2-Imidazolidinones
スポンサーリンク
概要
- 論文の詳細を見る
New optically active antifungal azoles, 1-[(1R, 2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-substituted phenyl)-2(1H, 3H)-imidazolones (1,2) and 2-imidazolidinones (3,4), were prepared in a stereocontrolled manner from (1S)-1-[(2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-oxi-ranyl]ethanols (15,16). Compounds 1-4 showed potent antifungal activity against Candida albicans in vitro and in vivo, as well as a broad antifungal spectrum for various fungi in vitro. Furthermore, the imidazolidinones, 3b-e and 4d, e, were found to exert extremely strong growth-inhibitory activity against Aspergillus fumigatus.
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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Yamada Makiko
San-ei Gen F.f.i. Inc.
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Tasaka A
Medicinal Chemistry Research Laboratories Pharmaceutical Research Division: Takeda Chemical Industri
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Tasaka Akihiro
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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Itoh K
Medicinal Chemistiy Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industr
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Itoh K
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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Yamada M
Pharmaceutical Research Division Takeda Pharmaceutical Company Limited
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Yoshida M
Tohoku Univ. Sendai Jpn
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KITAZAKI Tomoyuki
Medicinal Chemistry Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Indu
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MATSUSHITA Yoshihiro
Medicinal Chemistry Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Indus
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ITOH Katsumi
Medicinal Chemistry Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Indus
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HAYASHI Ryogo
Pharmacology Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries,
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TASAKA Akihiro
Medicinal Chemistry Research Laboratories Pharmaceutical Research Division
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Tamura N
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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Tamura N
Medicinal Chemistry Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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Itoh Katsumi
Medicinal Chemistiy Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industr
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Itoh K
Graduate School Of Pharmaceutical Sciences Chiba University:nisshin Seifun Group Inc.
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HOSONO Hiroshi
Pharmaceutical Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industrie
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TAMURA Norikazu
Medicinal Chemistry Laboratories, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.
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OKONOGI Kenji
Pharmacology Laboratories, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.,
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Itoh Kinuyo
Department Of Materials Chemistry & Frontier Research Center Graduate School Of Engineering. Osa
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Itoh Kunihiko
Dept. Pharmaceutical Sciences Akita University
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Hayashi R
Pharmacology Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries Lt
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Tamura N
Takeda Chemical Ind. Ltd. Osaka Jpn
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Okonogi K
Pharmacology Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries Ltd
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Okonogi Kenji
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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Hosono H
Medicinal Chemistry Research Laboratories Pharmaceutical Research Division: Takeda Chemical Industri
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Kitazaki T
Pharmaceutical Research Division Takeda Pharmaceutical Company Limited
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