Effects of Medium-chain Fatty Acids and Their Acylglycerols on the Transport of Penicillin V across Caco-2 Cell Monolayers

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概要

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• The transport-enhancing effects of medium-chain fatty acids (caproic, caprylic, and capric acids) and their acylglycerols (mono-, di-, and triacylglycerols) were investigated by using Caco-2 cell monolayers as a model of the human intestinal epithelium. Penicillin V was used as a model for a hydrophilic bioactive compound. Among the fatty acids and acylglycerols tested, 1, 2-dicaproin, monocaprin, monocaprylin, and capric acid sodium salt effectively enhanced the transport rate, whereas other substances enhanced the rate only slightly or not at all. With each of these four substances, the rate of enhancement was proportional to the concentration at low concentrations, but leveled off at high concentrations. The transport-enhancing effects were well correlated with the reduction in surface tension and with a physico-chemical parameter, denoted by the surface energy-lowering coefficient, characterizing the surface activity of a substance.

• 社団法人日本農芸化学会の論文
• 1997-07-23

著者

• ADACHI Shuji

  Department of Radiology, Hyogo Cancer Center

• Kimura Yoshinobu

  The International Center For Biotechnology Osaka University

• Yamada Makiko

  San-ei Gen F.f.i. Inc.

• ADACHI Shuji

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Kimura Y

  Department Of Biological And Environmental Chemistry Faculty Of Agriculture Tottori University

• Adachi S

  Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.

• Adachi Shuji

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• MATSUNO Ryuichi

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Yamaguchi Masayo

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Shima Motohiro

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Kimura Yukitaka

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• Yamaguchi M

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• SHIMA Motohiro

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• YOHDOH Kaori

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• YAMAGUCHI Masayo

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• MATUNO Ryuichi

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• Yohdoh Kaori

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University:(present Address)j

• Matsuno R

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Yamaguchi M

  Murata Manufacturing Co. Ltd.

• Adachi Shuji

  Department Of Food Sciencc And Tethnology Faculty Of Agriculture Kyoto University

• Yamaguchi Magoichi

  Research Institute Nihon Shokuhin Kako Co. Ltd.

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