Effect of Long-Term ‘Corn Peptide’ Ingestion on Alcohol Metabolism in Stroke-Prone Spontaneously Hypertensive Rats with Alcohol Loading

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概要

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• The effect of long-term ‘corn peptide (CP)’ ingestion on alcohol metabolism was investigated in stroke-prone spontaneously hypertensive rats (SHR-SP) with alcohol loading. Long-term CP ingestion in the EtOH/CP group did not significantly increase plasma GOT and GPT activities but markedly increased hepatic ADH and ALDH activities. Intragastric CP administration prior to a dose of 1.0g/kg ethanol significantly lowered the blood ethanol concentration in SHR-SP which had been loaded with ethanol for a long time. Compared with non-loaded SHR-SP (control group), the rats loaded for a long time with ethanol (EtOH group) showed high concentrations of taurine, glycine and histidine in the plasma. The plasma threonine and proline concentrations were significantly elevated by long-term CP ingestion (EtOH/CP group), but the plasma alanine concentration was rather decreased. These results suggest that short or long-term CP ingestion may enhance the alcohol metabolism within the body because of an increase in ADH and ALDH activities as well as the alleviation of alcohol-related hepatic injury.

• 財団法人 学会誌刊行センターの論文

著者

• Yamada Makiko

  San-ei Gen F.f.i. Inc.

• Yamaguchi Masayo

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Nozaki Osamu

  Department Of Clinical Pathology Kinki University School Of Medicine

• Yamaguchi M

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• NISHIKIORI Fumi

  Research Institute, Nihon Shokuhin Kako Co., Ltd.

• Yamaguchi M

  Murata Manufacturing Co. Ltd.

• Ito Michiko

  Department Of Anesthesiology International Medical Center Of Japan

• Nishikiori F

  Research Institute Nihon Shokuhin Kako Co. Ltd.

• Yamaguchi Magoichi

  Research Institute Nihon Shokuhin Kako Co. Ltd.

• Furukawa Yuji

  Department Of Material Science Graduate School Of Science And Technology Kobe University

• Nishikiori Fumi

  Research Institute Nihon Shokuhin Kako Co. Ltd.

• ITO Michiko

  Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University

• FURUKAWA Yuji

  Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University

• NOZAKI Osamu

  Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University

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