Tableting of Coated Particles. I. Small Particle Size Chitosan as an Agent Protecting Coating Membrane from Mechanical Damage of Compression Force

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概要

• 論文の詳細を見る

• Formulation of sustained release tablets containing coated particles whose coating membrane is not damaged during compression was studied and several kinds of chitosan of different particle size were evaluated as protective agents for the membrane. Comparison was made with the dissolution rate of the coated particles. Ethylcellulolse or ethylcellulose/hydroxypropylcellulose was chosen as a coating agent. When the coated particles were compressed with the small particle size chitosan (Marine Chito), the coating membrane was not ruptured, and the protective effect was not influenced by the compression pressure. Both the Eudragit RS-coated particles and the tablets manufactured by compressing the coated particles with Marine Chito were orally administered to dogs, and the plasma theophylline levels of the two dosage forms were compared to determine the drug release characteristics in the gastrointestinal tract. It was found that the plasma concentration-time curve of the tablets coincided with that of the coated particles, and the compressed tablet would disintegrate instantly and redisperse into many particles in the body after oral administration.

• 公益社団法人日本薬学会の論文
• 1997-09-15

著者

• Yamada Makiko

  San-ei Gen F.f.i. Inc.

• Yamada M

  Pharmaceutical Research Division Takeda Pharmaceutical Company Limited

• Yao Takashi

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd. :(present Address)production Technology Di

• Yoshida M

  Tohoku Univ. Sendai Jpn

• Yoshida M

  Takamatsu Works Inui Corporation

• YAMADA Misuzu

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• YAMAHARA Hiroshi

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• YOSHIDA Masanori

  Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• Yamahara H

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.

• Yamahara Hiroshi

  Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.

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