Protective Effects of Dietary Nasunin on Paraquat-induced Oxidative Stress in Rats

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概要

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• The preventive effects of nasunin (delphinidin-3-[4-p-coumaroyl-rhamnosyl (1→6) glucoside]-5-glucoside) on paraquat-induced oxidative stress were determined in rats. Decreased food intake and body weight gain and increased lung weight by feeding the rats a diet containing paraquat were clearly suppressed by supplementing nasunin to the paraquat diet. Paraquat feeding increased the concentration of thiobarbituric acid-reactive substances (TBARS) in liver lipids and the atherogenic index, and decreased the liver triacylglycerol level. These effects were also suppressed by supplementing nasunin to the paraquat diet. In addition, catalase activity in the liver mitochondrial fraction was markedly decreased by feeding the paraquat diet, this decrease being partially suppressed by supplementing the paraquat diet with nasunin. These results suggest that nasunin acted preventively against the oxidative stress in vivo that may have been due to active oxygen species formed through the action of paraquat.

• 社団法人日本農芸化学会の論文
• 1999-05-23

著者

• Kimura Yoshinobu

  The International Center For Biotechnology Osaka University

• Kimura Y

  Department Of Biological And Environmental Chemistry Faculty Of Agriculture Tottori University

• Araki Yoshio

  Division Of Gastroenterology Shiga University Of Medical Science

• IKAWA-KITAYAMA Kaori

  Tochigi Research Laboratories of Kao Corporation

• Igarashi Kaori

  Graduate School Of Human Life Sciences Showa Women's University

• TAKENAKA Asako

  Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo

• Takenaka A

  Department Of Bioproduction Faculty Of Agriculture Yamagata University

• Takenaka Asako

  山形大学 農学部生物資源学科

• Takenaka Asako

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Takenaka Asako

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• IGARASHI Kiharu

  Department of Agricultural Chemistry, Faculty of Agriculture, Yamagata University

• Igarashi Kiharu

  Department Of Agricultural Chemistry Faculty Of Agriculture Yamagata University

• Igarashi K

  Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers

• KIMURA Yuriko

  Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University

• ARAKI Yumi

  Department of Bioresourse Engineering, Faculty of Agriculture, Yamagata University

• Araki Yumi

  Department Of Bioresourse Engineering Faculty Of Agriculture Yamagata University

• Takenaka Asako

  Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University

• ARAKI Yumi

  Department of Bioproduction, Faculty of Agriculture, Yamagata University

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