Disruption of ins-11, a Caenorhabditis elegans Insulin-Like Gene, and Phenotypic Analyses of the Gene-Disrupted Animal
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概要
- 論文の詳細を見る
The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode Caenorhabditis elegans. One of 38 C. elegans insulin-like genes, ins-11, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, ins-7. Hence ins-11 appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the C. elegans insulin-like gene that suppresses the lifespan extension.
- 2006-12-23
著者
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Kimura Y
Department Of Bioresource Science Faculty Of Agriculture Tottori University
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KIMURA Yasuo
Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University
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Kimura Y
Department Of Biological And Environmental Chemistry Faculty Of Agriculture Tottori University
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KAWANO Tsuyoshi
Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
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Kimura Yasuo
Department Of Biological And Environmental Chemistry Tottori University
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GENGYO ANDO
Department of Physiology, Tokyo Wemen's Medical University
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MITANI Shohei
Department of Physiology, Tokyo Wemen's Medical University
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NAGATOMO Ryosuke
Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
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Gengyo Ando
Department Of Physiology Tokyo Wemen's Medical University
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Mitani Shohei
Department Of Physiology Tokyo Wemen's Medical University
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Kawano Tsuyoshi
Department Of Bioresource Sciences Faculty Of Agriculture Tottori University
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Kawano Tsuyoshi
Department Of Biological And Environmental Chemistry Faculty Of Agriculture Tottori University
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Kawano Tsuyoshi
Dep. Of Bioresource Sciences Fac. Of Agriculture Tottori Univ.
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Kawano Tsuyoshi
Department Of Biological And Environmental Chemistry Tottori University
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Kimura Yasuo
Department Of Agricultural Chemistry Faculty Of Agriculture Tottori University
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Kimura Y
Department Of Biological And Environmental Chemistry Tottori University
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Nakatomo Ryosuke
Department Of Biological And Environmental Chemistry Tottori University
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MITANI Shohei
Department of Pharmacology, Faculty of Medicine, The University of Tokyo
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