Production of Isopropyl cis-6-Hexadecenoate by Regiospecific Desaturation of Isopropyl Palmitate by a Double Mutant of a Rhodococcus Strain

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概要

• 論文の詳細を見る

• Resting cells of a double mutant noted as KSM-MT66,derived from Rhodococcus sp. strain KSM-B-3 by UV irradiation, were found to cis-desaturate isopropyl hexadecanoate, yielding isopropyl cis-6-hex-adecenoate. Addition of sodium glutamate (1.0%), Mg SO_4 (2 mM), and thiamine (2 mM) increased the productivity of the unsaturated product in phosphate buffer. Optimal temperature and pH for the reaction were around 26℃ and 7,respectively. Under the optimized conditions, more than 50 g/I of isopropyl cis-6-hexadecenoate was produced after a 3-day incubation by resting cells of the mutant. Thus, cis-6-hexadecenoic acid, the main component of human sebaceous lipids, can be manufactured economically by the rhodococcal bioconversion.

• 社団法人日本農芸化学会の論文
• 2000-02-23

著者

• Kimura Yoshinobu

  The International Center For Biotechnology Osaka University

• Kimura Y

  Department Of Biological And Environmental Chemistry Faculty Of Agriculture Tottori University

• Kimura Y

  Department Of Agricultural Science Faculty Of Agriculture Okayama University

• Koike K

  Faculty Of Pharmaceutical Sciences Toho University

• Ito S

  Extremobiosphere Research Center Of Japan Agency For Marine-earth Science And Technology (jamstec):c

• ITO Susumu

  Tochigi Research laboratories, Kao Corporation

• Koike Kenzo

  Tochigi Research Laboratories, Kao Corporation

• ARA Katsutoshi

  Tochigi Research Laboratories of Kao Corporation

• Inoue S

  Tochigi Research Laboratories Of Kao Corporation

• TAKAIWA Mikio

  Tochigi Research Laboratories of Kao Corporation

• KIMURA Yoshiharu

  Tochigi Research Laboratories of Kao Corporation

• INOUE Shigeo

  Tochigi Research Laboratories of Kao Corporation

• Koike K

  Tochigi Research Laboratories Kao Corporation

• Ito S

  National Industrial Research Institute

• Takaiwa M

  Tochigi Research Laboratories Of Kao Corporation

• Sugimoto Isamu

  Division Of Pathological Biochemistry Department Of Biomedical Sciences School Of Life Sciences Facu

• Kimura Y

  Mukogawa Women's Univ. Nishinomiya Jpn

• Kimura Y

  Department Of Biological And Environmental Chemistry Tottori University

• Ito Susumu

  Tochigi Research Laboratories Kao Corporation

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