Soy Protein Suppresses Gene Expression of Acetyl-CoA Carboxylase Alpha from Promoter PI in Rat Liver
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概要
- 論文の詳細を見る
Dietary soy protein isolate (SPI) reduces hepatic lipogenesis by suppressing gene expression of lipogenic enzymes, including acetyl-CoA carboxylase (ACC). In order to elucidate the mechanism of this regulation, the effect of dietary SPI on promoter (PI and PII) specific gene expression of ACC alpha was investigated. Rats were fed experimental diets containing SPI or casein as a nitrogen source. SPI feeding decreased the hepatic contents of total ACC mRNA as well as triglyceride (TG) content, but dietary SPI affected the amount of sterol-regulatory element binding protein (SREBP)-1 mRNA and protein very little. The amount of ACC mRNA transcribed from PII promoter containing SRE was not significantly affected by dietary protein, while a significant decrease in PI-generated ACC mRNA content was observed in rats fed the SPI diet. These data suggest that SPI feeding decreased the hepatic contents of ACC alpha mRNA mainly by regulating PI promoter via a nuclear factor(s) other than SREBP-1.
- 社団法人 日本農芸化学会の論文
- 2006-04-23
著者
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Aoki H
Iwate Univ. Iwate Jpn
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Aoki Hideyuki
Research Laboratory Ikeda Food Research Co. Ltd.
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Aoki H
Ikeda Food Res. Co. Ltd. Hiroshima Jpn
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KIMURA Kumi
Department of Cardiology, Fukuoka University School of Medicine
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IKAWA-KITAYAMA Kaori
Tochigi Research Laboratories of Kao Corporation
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Igarashi Kaori
Graduate School Of Human Life Sciences Showa Women's University
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TAKENAKA Asako
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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Takenaka A
Department Of Bioproduction Faculty Of Agriculture Yamagata University
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Takenaka Asako
山形大学 農学部生物資源学科
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Takenaka Asako
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Takenaka Asako
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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IGARASHI Kiharu
Department of Agricultural Chemistry, Faculty of Agriculture, Yamagata University
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Igarashi Kiharu
Department Of Agricultural Chemistry Faculty Of Agriculture Yamagata University
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Igarashi K
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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AOKI Hisa
Course of the Science of Bioresources, The United Graduate School of Agricultural Sciences, Iwate Un
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Kimura Kumi
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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Takenaka Asako
Department Of Agricultural Chemistry Faculty Of Agriculture Meiji University
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