Dietary Vitamin E Deficiency Increases Anxiety-Like Behavior in Juvenile and Adult Rats
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概要
- 論文の詳細を見る
Vitamin E deficiency from birth or infancy has recently been found to increase anxiety-like behavior in rodents. The present study was undertaken to elucidate the effect of dietary vitamin E deficiency on anxiety in adult rats in comparison with juvenile rats. Male Wistar rats, 3 or 10 weeks old, were divided into two groups and fed a control or vitamin E-deficient diet for 4 weeks. The results of behavioral analysis revealed that vitamin E-deficiency increased anxiety in both juvenile and adult rats. Plasma, liver, and brain α-tocopherol concentrations decreased significantly due to vitamin E deficiency in both age groups. Plasma corticosterone concentrations were higher in the vitamin E-deficient rats in response to the stress of a behavioral test. Based on these results, we conclude that dietary vitamin-E deficiency induces anxiety in adult rats as well as juvenile rats. This might be due to an elevated plasma corticosterone concentration.
- 社団法人 日本農芸化学会の論文
著者
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Takenaka Asako
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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TERADA Yuki
Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
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OKURA Yuki
Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University
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KIKUSUI Takefumi
Companion Animal Research, School of Veterinary Medicine, Azabu University
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- Dietary Vitamin E Deficiency Increases Anxiety-Like Behavior in Juvenile and Adult Rats
- Dietary Vitamin E Deficiency Increases Anxiety-Like Behavior in Juvenile and Adult Rats