Blood Pressure-Depressing Activity of a Peptide Derived from Silkworm Fibroin in Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
Peptides showing inhibitory activity against the angiotensin I-converting enzyme (ACE) were investigated from the fibroin fraction of discarded silk fabric. Fibroin, which was hydrolyzed with alcalase after partial hydrolysis with hot aqueous 40% CaCl2, released two major active peptides showing ACE-inhibitory activity. The two peptides were identified as glycyl-valyl-glycyl-tyrosine (GVGY) and glycyl-valyl-glycyl-alanyl-glycyl-tyrosine (GVGAGY) by analyses with a protein sequencer and LC/MS/MS. GVGY, whose ACE-inhibitory activity has not previously been reported, showed a blood pressure-depressing effect on spontaneously hypertensive rat (SHR).
- 社団法人 日本農芸化学会の論文
- 2006-02-23
著者
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MIYAKOSHI Masazumi
Maruzen Pharmaceutical Co., Ltd
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MURAKAMI Toshiyuki
Maruzen Pharmaceutical Co., Ltd
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Mizutani Kenji
School Of Agriculture Tokai University
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Korematsu Yoshiaki
Faculty Of Pharmaceutical Sciences Fukuoka University
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AKIZAWA Toshifumi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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Mishima Kenji
School Of Agriculture Tokai University
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Mizutani Kenji
Research Laboratory Maruzen Pharmaceuticals Co. Ltd.
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IGARASHI Kiharu
Department of Agricultural Chemistry, Faculty of Agriculture, Yamagata University
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Igarashi Kiharu
Department Of Agricultural Chemistry Faculty Of Agriculture Yamagata University
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Miyakoshi Masazumi
Maruzen Pharmaceutical Co. Ltd
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Miyakoshi Masazumi
Research Center Maruzen Pharmaceuticals Co. Ltd.
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Akizawa Toshifumi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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YOSHIOKA Kosuke
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University
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MURAKAMI Toshiyuki
Research Center, Maruzen Pharmaceuticals Co., Ltd.
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Murakami Toshiyuki
Maruzen Pharmaceutical Co. Ltd
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Mizutani Kenji
Research Center Maruzen Pharmaceuticals Co. Ltd.
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