MARINOIC ACID, A NOVEL BUFADIENOLIDE-RELATED SUBSTANCE IN THE SKIN OF THE GIANT TOAD, Bufo marinus
スポンサーリンク
概要
- 論文の詳細を見る
We found a novel substance, 3β-hydroxy-11,12-seco-5β, 14β-bufa-20,22-dienolide-11,14-olide-12-oic acid (1), which we called marinoic acid, in the skin of the toad, Bufo marinus. The structure was established from NMR and MS data. Like bufadienolides, marinoic acid contained an A/B ring structure in the cis configuration and a D/α-pyrone ring structure, but the structure of the C ring differed considerably from that of bufadienolides. Marinoic acid exhibited biological activity, as demonstrated by inhibition of Na^+, K^+-ATPase enzymatic activity, and by inhibition of [^3H]ouabain binding to the digitalis receptor site on Na^+, K^+-ATPase, although marinoic acid was a less effective inhibitor than typical bufadienolides. Although marinoic acid cannot be classified as a bufadienolide, its chemical structure and its Na^+, K^+-ATPase inhibitory activity suggest that it is bufadienolide-related.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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Yoshioka Masanori
Faculty of Pharmaceutical Sciences, Setsunan University
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Butler Jr.
Department Of Medicine College Of Physicians & Surgeons Of Columbia University
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AKIZAWA Toshifumi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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MORRIS Jennifer
Department of Medicine, College of Physicians & Surgeons of Columbia University
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MATSUKAWA Motomi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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Morris Jennifer
Department Of Medicine College Of Physicians & Surgeons Of Columbia University
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YOSHIOKA Masanori
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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Akizawa Toshifumi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Yoshioka M
Faculty Of Pharmaceutical Sciences Setsunan University
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MATSUKAWA Motomi
Faculty of Pharmaceutical Sciences, Setsunan University
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Yoshioka Masanori
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Matsukawa M
Setsunan Univ. Osaka Jpn
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Matsukawa Motomi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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