STRUCTURES OF NOVEL BUFADIENOLIDES IN THE EGGS OF A TOAD, Bufo marinus
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概要
- 論文の詳細を見る
In this paper, we report chemical structures of five compounds including four novel polyhydroxylated cardiac steroids in the eggs of a toad, Bufo marinus. These cardiac steroids were purified by high-performance liquid chromatography, and their structrues were determined to be 11α, 19-dihydroxytelocinobufagin (I), 11α-hydroxytelocinobufagin (II), 11α, 19-dihydroxymarinobufagin (III), 11α-hydroxymarinobufagin (IV) and 19-hydroxytelocinobufagin (V) on the basis of spectral data of nuclear magnetic resonance and mass spectroscopy. All the five compounds showed biological activity, as tested by inhibition of Na^+, K^+-ATPase activity and of [^3H]ouabain binding to the receptor on Na^+, K^+-ATPase. This is the first finding of bufadienolides as cardiac steroids in animal eggs.
- 公益社団法人日本薬学会の論文
- 1994-03-15
著者
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吉岡 正則
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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吉岡 正則
摂南大学薬学部
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吉岡 正則
摂南大・薬・薬品分析化学
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秋澤 俊史
摂南大学薬学部
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吉岡 正則
摂南大 薬
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Butler V
Coll. Physicians & Surgeons Of Columbia Univ. N.y. Usa
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松川 元美
摂南大・薬
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秋澤 俊史
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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向井 努
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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松川 元美
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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MORRIS Jennifer
Department of Medicine, College of Physicians & Surgeons of Columbia University
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BUTLER Vincent
Department of Medicine, College of Physicians & Surgeons of Columbia University
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Butler Vincent
Department Of Medicine College Of Physicians & Surgeons Of Columbia University
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Morris Jennifer
Department Of Medicine College Of Physicians & Surgeons Of Columbia University
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向井 努
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Setsunan University
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