Effects of Germinated Barley Foodstuff on Microflora and Short Chain Fatty Acid Production in Dextran Sulfate Sodium-induced Colitis in Rats.
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概要
- 論文の詳細を見る
Germinated barley foodstuff (GBF) administration has been previously reported to suppress dextran sulfate sodium (DSS)-induced experimental colitis. In this study, we investigated the roles of the intestinal microflora and short chain fatty acids (SCFAs) following administration of GBF in DSS-induced rat colitis. Sprague-Dawley rats were fed 3% (w/w of diet) DSS in GBF-diets for 5 days. The control rats were fed 3% DSS in cellulose-diets for 5 days. The administration of GBF effectively prevented bloody diarrhea and mucosal damage as compared to control rats. GBF significantly elevated fecal acetic acid and n-butyric acid levels. GBF tended to increase the number of eubacteria and that of bifidobacteria as compared to control rats. In addition, the number of enterobacteriaceae, the total number of aerobes and bacteroidaseae, were significantly lower in rats fed GBF than in the control group. It is suggested that the therapeutic effects of GBF for DSS-induced colitis depend mainly on increased SCFAs, which are accompanied by changes of composition of intestinal bacteria.
- 社団法人日本農芸化学会の論文
- 2000-09-23
著者
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KANAUCHI Osamu
Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Co. Ltd.
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FUJIYAMA Yoshihide
Department of Internal Medicine, School of Medicine, Shiga University of Medical Science
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KANAUCHI OSAMU
Nutrient Food and Feed Division, Kirin Brewery
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ARAKI YOSHIO
Department of Internal Medicine, Shiga University of Medical Science
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ANDOH AKIRA
Department of Internal Medicine, Shiga University of Medical Science
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BAMBA TADAO
Department of Internal Medicine, Shiga University of Medical Science
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KOYAMA SHIGEKI
Department of Gastroenterology, Shiga University of Medical Science
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Araki Yoshio
Division Of Gastroenterology Shiga University Of Medical Science
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Koyama Shigeki
Division Of Gastroenterology Shiga University Of Medical Science
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Koyama Shigeki
Department Of Gastroenterology Shiga University Of Medical Science
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Bamba Tadao
Department Of Gastroenterology Shiga University Of Medical Sciencs
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Fujiyama Yoshihide
Department Of Gastroenterology And Hematology Shiga University Of Medical Science
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Araki Yumi
Department Of Bioresourse Engineering Faculty Of Agriculture Yamagata University
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Andoh Akira
Department Of Medicine Shiga University Of Medical Science
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Andoh Akira
Department Of Gastroenterology Shiga University Of Medical Sciencs
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Bamba T
Second Department Of Internal Medicine Shiga University Of Medical Science
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Kanauchi O
Kirin Brewery Co. Ltd. Tokyo Jpn
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Kanauchi Osamu
Applied Bioresearch Center Corporate Research And Development Division Kirin Brewery Co. Ltd.
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Araki Yoshio
Department Of Environmental Molecular Biology Graduate School Of Environmental Earth Science Hokkaid
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ARAKI YOSHIO
Department of Anatomy, Kurume University School of Medicine
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