Improvement of Physicochemical Properties of N-4472. Part III. VC/N-4472 Complex Formation and Self-association in Aqueous Solution

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概要

• 論文の詳細を見る

• To improve the aqueous solubility of a poorly water-soluble drug, N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-[4-(N-benzylpiperidyl)]urea (N-4472), organic acidlN-4472 evaporates were prepared by using succinic acid, L-tartaric acid, citric acid and L-ascorbic acid (VC). Among these evaporates, only the VC/N-4472 evaporate at a molar ratio of more than 2 (VC/N-4472) formed stable colloidal particles (with a mean particle size ≤ 100 nm) in aqueous solution. In particular, the evaporate prepared at the molar ratio of 5 (VC/N-4472) formed a clear solution comprising tine particles with a narrow particle size distribution of 8-15 nm. On the basis of surface tension measurement, zeta potential determination and static light scattering measurement, it was conceivable that both N-4472 and VC contributed to the formation of a surface-active complex in aqueous solution, while the colloidal particles could be interpreted as the self-association product of these complexes. According to the findings on ^1H-NMR and attenuated total reflectance Fourier transform infrared spectra, it was postulated that upon combining both components at a molar ratio of 2 (VC/N-4472), a 1:1 association complex of N-4472 and VC was formed, whereas the higher order complexes were assumedly formed with use of a molar ratio of more than 2 (VC/N-4472). Furthermore, it was evidenced that all of these complexes were composed of amphiphilic structures comprising both hydrophobic N-4472 moiety and hydrophilic VC moiety, thereby properly accounting for surface-active property of these complexes.

• 社団法人日本薬学会の論文
• 2003-01-01

著者

• Yamamoto K

  Graduate School Of Pharmaceutical Sciences Chiba University

• ITOH Koichi

  Graduate School of Science, Osaka City University

• Yamamoto Keiji

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamaguchi K

  Tokushima Bunri Univ. Sanuki‐city Jpn

• TOZUKA Yuichi

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yuichi Tozuka

  Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University

• OGUCHI Toshio

  Graduate School of Pharmaceutical Sciences, Chiba University

• Oguchi T

  Department Of Pharmacy University Hospital University Of Yamanashi

• Itoh Koichi

  Clinical Laboratory Medicine, Jichi Medical School

• Oguchi Toshio

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamaguchi Kentaro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus

• Yamamoto Keiji

  Graduate School Of Pharmaceutical Sciences Chiba University

• Itoh Koichi

  Clinical Laboratory Medicine Jichi Medical School

• Itoh Koichi

  Graduate School Of Science Osaka City University

• Itoh K

  Graduate School Of Pharmaceutical Sciences Chiba University:nisshin Seifun Group Inc.

• Itoh Koichi

  Graduate School of Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan

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