Micronization of Phenylbutazone by Rapid Expansion of Supercritical CO_2 Solution
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概要
- 論文の詳細を見る
Rapid expansion of supercritical solutions (RESS) technique was applied for the preparation of phenylbutazone fine particles. The operating temperature and pressure affected the yield of the drug fine particles, which was evaluated by dissolving the sprayed product of drug into ethanol. Effect of pre- and post-expansion conditions on the particle size distribution of phenylbutazone was investigated and the smallest sample (mean particle size: 1.59μm) was obtained when the RESS method was operated at a pressure of 26MPa combined with a temperature of 32℃. Physicochemical properties of the fine particles were investigated by powder X-ray diffraction and differential scanning calorimetry. It was found that the phenylbutazone fine particles obtained were metastable β form under the experimental conditions tested, suggesting polymorphic transformation during the RESS process.
- 社団法人日本薬学会の論文
- 2005-08-01
著者
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Yamamoto K
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamamoto Keiji
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamaguchi K
Tokushima Bunri Univ. Sanuki‐city Jpn
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TOZUKA Yuichi
Graduate School of Pharmaceutical Sciences, Chiba University
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OGUCHI Toshio
Department of Pharmacy, University Hospital, Faculty of Medicine, University of Yamanashi
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Yuichi Tozuka
Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University
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TSUTSUMI Shunichiro
Graduate School of Pharmaceutical Sciences, Chiba University
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MORISHITA Shoko
Graduate School of Pharmaceutical Sciences, Chiba University
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SHINOZAKI Hiroshi
Graduate School of Pharmaceutical Sciences, Chiba University
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Tsutsumi Shun-ichiro
Graduate School of Pharmaceutical Sciences, Chiba University
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Oguchi T
Department Of Pharmacy University Hospital University Of Yamanashi
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Oguchi Toshio
Department Of Pharmacy University Hospital University Of Yamanashi
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Oguchi Toshio
Faculty Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Faculty Of Pharmaceutical Sciences Teikyo University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba University
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Yamaguchi Kentaro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus
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Yamamoto Keiji
Graduate School Of Pharmaceutical Sciences Chiba University
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Morishita Shoko
Graduate School Of Pharmaceutical Sciences Chiba University
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Tsutsumi Shun-ichiro
Graduate School Of Pharmaceutical Sciences Chiba University
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Shinozaki Hiroshi
Graduate School Of Pharmaceutical Sciences Chiba University:cmc Development Department Nihon Scherin
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Tsutsumi Shunichiro
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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