Elucidation of Solid-State Complexation in Ground Mixtures of Cholic Acid and Guest Compounds

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概要

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• The solid-state complexation between cholic acid (CA) and either methyl p-hydroxybenzoate (MPB) or ibuprofen (IBP) was investigated. Powder X-ray diffractometry, IR spectroscopy and thermal analysis suggested the complex formation between CA and MPB as well as between CA and IBP by co-grinding method. The stoichiometry of CA-MPB was 1:1 while that of CA-IBP was 2:1, reflecting the effect of guest size on complex formation. The guest compounds were assumed to be included in the channel of complexes formed by hydrogen bonds among CA molecules.

• 社団法人日本薬学会の論文
• 2002-07-01

著者

• Yamamoto K

  Graduate School Of Pharmaceutical Sciences Chiba University

• Yamamoto Keiji

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamaguchi K

  Tokushima Bunri Univ. Sanuki‐city Jpn

• TOZUKA Yuichi

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yuichi Tozuka

  Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University

• OGUCHI Toshio

  Graduate School of Pharmaceutical Sciences, Chiba University

• HANAWA Takehisa

  Graduate School of Pharmaceutical Sciences, Chiba University

• MIZUTANI Mayuko

  Graduate School of Pharmaceutical Sciences, Chiba University

• SASAKI Nahomi

  Graduate School of Pharmaceutical Sciences, Chiba University

• LIMMATVAPIRAT Sontaya

  Faculty of Pharmacy, Silpakorn University

• Oguchi T

  Department Of Pharmacy University Hospital University Of Yamanashi

• Oguchi Toshio

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamaguchi Kentaro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus

• Yamamoto Keiji

  Graduate School Of Pharmaceutical Sciences Chiba University

• Sasaki Nahomi

  Graduate School Of Pharmaceutical Sciences Chiba University

• Morita M

  Graduate School Of Pharmaceutical Sciences Chiba University

• Hanawa T

  Graduate School Of Pharmaceutical Sciences Chiba University

• Limmatvapirat Sontaya

  Faculty Of Pharmacy Silpakorn University

• Hanawa Takehisa

  Graduate School Of Pharmaceutical Sciences Chiba University

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