Dissolution of DEHP from PVC Administration Tube : Estimation of DEHP Dissolution Based on HCO 60 Concentration and Drip Conditions
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概要
- 論文の詳細を見る
Di- 2 -ethylhexyl Phthalate (DEHP) is reported to have been formed and identified in a polyvinyl chloride (PVC) administration tube during the infusion of an injection fluid containing polyoxyethlated caster oil (HC060) as a solvilizing agent. This paper describes a experimental formula for estimating the amount of DEHP dissolution, which was obtained under several drip conditions and using an aqueous solution of HC060. The DEHP concentration was determined using HPLC. The DEHP dissolution followed a general pattern, in which the DEHP concentration in the solution linearly increased over time as first and thereafter reached a plateau. The amount of DEHP dissolution depended on the drip conditions. The maximum (plateau) DEHP concentration C_D (μg/mL) was proportional to the square root of the HC060 concentration C_H (mg/mL), the length of the tube H (cm) and the inner diameter of the tube R (cm), but was inversely proportional to the driprate S (mL/hr). The time T_1 (hr), which becomes C_D = aT_1 (a : inclination of the graph before reaching it in plateau), was proportional to H and R^2, but inversely proportional to S.T_1 was not dependent on C_H. Based on these results, the formula for calculating the total amount of dissolution of DEHP D_<total>(μg) during the total time of the infusion T (hr) was determined to be as follows : D_<total> =4.09RH√<C_H>(T-O.755R^2H/S) The application of this formula will make it easier to estimate the amount of DEHP intake by patients during the infusion of an injection containing HCO60 using a PVC administration tube.
- 日本医療薬学会の論文
- 2001-04-10
著者
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Suzuki Masahiko
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
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Kawano K
Niigata College Of Pharmacy
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KAWANO KENJI
Niigata College of Pharmacy
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TANAKA MUTSUKO
Niigata College of Pharmacy
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Hanawa Takehisa
Department of Pharmacy, Yamanashi Medical University
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Nakajima S
Department Of Pharmacy Yamanashi Medical University
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Hanawa T
Graduate School Of Pharmaceutical Sciences Chiba University
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Nakajima Shinichiro
Department of Hospital Pharmacy, Yamanashi Medical University
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Suzuki Masahiko
Department Of Pharmacy University Hospital University Of Yamanashi
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Suzuki Masahiko
Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University
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Nakajima S
Hospital Pharmacy Yamanashi Medical College
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Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Hanawa Takehisa
Department of Pharmacy, University Hospital, University of Yamanashi
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