Micronization of Phenylbutazone by Rapid Expansion of Supercritical CO2 Solution
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概要
- 論文の詳細を見る
Rapid expansion of supercritical solutions (RESS) technique was applied for the preparation of phenylbutazone fine particles. The operating temperature and pressure affected the yield of the drug fine particles, which was evaluated by dissolving the sprayed product of drug into ethanol. Effect of pre- and post-expansion conditions on the particle size distribution of phenylbutazone was investigated and the smallest sample (mean particle size: 1.59 μm) was obtained when the RESS method was operated at a pressure of 26 MPa combined with a temperature of 32 °C. Physicochemical properties of the fine particles were investigated by powder X-ray diffraction and differential scanning calorimetry. It was found that the phenylbutazone fine particles obtained were meta-stable β form under the experimental conditions tested, suggesting polymorphic transformation during the RESS process.
- 社団法人 日本薬学会の論文
著者
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Yamamoto K
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamamoto Keiji
Graduate School of Pharmaceutical Sciences, Chiba University
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TOZUKA Yuichi
Graduate School of Pharmaceutical Sciences, Chiba University
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OGUCHI Toshio
Department of Pharmacy, University Hospital, Faculty of Medicine, University of Yamanashi
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MORISHITA Shoko
Graduate School of Pharmaceutical Sciences, Chiba University
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SHINOZAKI Hiroshi
Graduate School of Pharmaceutical Sciences, Chiba University
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Tsutsumi Shun-ichiro
Graduate School of Pharmaceutical Sciences, Chiba University
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