Optically Active Antifungal Azoles. III. Synthesis and Antifungal Activity of Sulfide and Sulfonamide Derivatives of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H, 1,2,4-triazol-1-yl)-2-butanol
スポンサーリンク
概要
- 論文の詳細を見る
In an effort to find potent antifungal agents, optically active sulfur-containing triazole derivatives, sulfides (3) and sulfonamides (4), were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo. The sulfides (3) were prepared by the reaction of (2R, 3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H, 1,2,4-triazol-1-yl)-2-butanol (1) with various heteroarylmethyl chlorides in the presence of sodium methoxide. The sulfonamides (4) were synthesized starting from the disulfide (15) in three steps including oxidation of the corresponding sulfenamides (17). Some of the sulfur-containing triazole derivatives (3,4) showed strong protective effects against candidosis in mice.
- 社団法人日本薬学会の論文
- 1994-01-15
著者
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伊藤 克己
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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寺西 克倫
Pharmaceutical Research Laboratory Iii Pharmaceutical Research Division Takeda Chemical Industries L
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Tasaka A
Medicinal Chemistry Research Laboratories Pharmaceutical Research Division: Takeda Chemical Industri
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田坂 昭弘
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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Tasaka Akihiro
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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Itoh K
Medicinal Chemistiy Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industr
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Itoh K
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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松下 義弘
Pharmaceutical Research Laboratory III, Pharmaceutical Research Division, Takeda Chemical Industries
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田村 典一
Pharmaceutical Research Laboratory III, Pharmaceutical Research Division, Takeda Chemical Industries
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林 良吾
Pharmaceutical Research Laboratory III, Pharmaceutical Research Division, Takeda Chemical Industries
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小此木 研二
Pharmaceutical Research Laboratory III, Pharmaceutical Research Division, Takeda Chemical Industries
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Tamura N
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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田村 典一
武田薬品工業(株)
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Tamura N
Medicinal Chemistry Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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小此木 研二
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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Itoh Kinuyo
Department Of Materials Chemistry & Frontier Research Center Graduate School Of Engineering. Osa
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Itoh Kunihiko
Dept. Pharmaceutical Sciences Akita University
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Hayashi R
Pharmacology Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries Lt
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Tamura N
Takeda Chemical Ind. Ltd. Osaka Jpn
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Matsushita Y
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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松下 義弘
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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松下 義弘
Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.
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