Synthesis and Human Immunodeficiency Virus (HIV)-1 Protease Inhibitory Activity of Tripeptide Analogues Containing a Dioxoethylene Moiety

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概要

• 論文の詳細を見る

• Tripeptide analogues 2 and 3 containing a dioxoethylene moiety were designed based on the characteristic structure of the naturally occurring human immunodeficiency virus (HIV)-1 protease inhibitors RPI-856 A, B, C and D (1). The compounds (2,3) prepared showed high inhibitory activity, comparable to that of RPI-856 A, against HIV-1 protease in vitro.

• 公益社団法人日本薬学会の論文
• 1994-12-15

著者

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 岸本 彰二

  Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd.,

• 岸本 彰二

  Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.

• 伊藤 克巳

  武田薬品工業

• 岸本 彰二

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 加藤 光一

  Discovery Research Laboratories I Discovery Research Division Takeda Chemical Industries Ltd.

• 北崎 智幸

  Pharmaceutical Research Laboratories III, Pharmaceutical Research Division, Takeda Chemical Industri

• 浅野 常夫

  Discovery Research Laboratories I, Discovery Research Division, Takeda Chemical Industries, Ltd.,

• 北崎 智幸

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 浅野 常夫

  Discovery Research Laboratories I Discovery Research Division Takeda Chemical Industries Ltd.

• 北崎 智幸

  Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited

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