Synthesis of 3-Aryl-6-aminocyclohex-2-enol Derivatives

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概要

• 論文の詳細を見る

• 6-(N-Substituted amino)-3-arylcyclohex-2-enol (7) was designed as a new type of β-adrenergic blocker on the basis of the X-ray crystallographic data for propranolol. Eight such compounds (7) were prepared by a six-step sequence of reactions from 3-arylcyclohex-2-enone (8), and tested for β-blocking activity in vitro. A weak β-blocking activity was exhibited by 6-(1-methyl-3-phenylpropyl) amino-3-phenylcyclohex-2-enol (7e).

• 公益社団法人日本薬学会の論文
• 1983-06-25

著者

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 岡 良和

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 伊藤 克巳

  武田薬品工業

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 伊藤 克己

  Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.,

• 岡 良和

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 岡 良和

  Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

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