Design and Synthesis of N-[N-[(S)-1-Ethoxycarbonyl-3-phenylprolyl]-L-alanyl]-N-(indan-2-yl)glycine (CV-3317), a New, Potent Angiotensin Converting Enzyme Inhibitor

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概要

• 論文の詳細を見る

• A new angiotensin converting enzyme (ACE) inhibitor, N-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-N-(indan-2-yl)glycine (9a), was found as a result of extensive studies on the structural requisites for the C-terminal amino acid moiety in ACE inhibitors. The synthesis and the determination of the absolute configuration of 9a are described.

• 公益社団法人日本薬学会の論文
• 1986-07-25

著者

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 岡 良和

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 伊藤 克巳

  武田薬品工業

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 伊藤 克己

  Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.,

• 岡 良和

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 岡 良和

  Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

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