Synthesis and Biological Activities of 3-Aminomethyl-1,2-dihydronaphthalene Derivatives

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概要

• 論文の詳細を見る

• A series of 3-aminomethyl-1,2-dihydronaphthalene derivatives (6-22) was prepared from the corresponding 3,4-dihydro-1 (2H)-naphthalenone derivatives (24a-q) in three steps, namely the Mannich reaction, reduction of the carbonyl group with sodium borohydride, and dehydration with ethanolic hydrogen chloride. Compounds 6-22 and several related analogs (23,27-30) were tested for vasodilating and antihypertensive activities. Potent cerebral vasodilating and antihypertensive activities were exhibited by 1-benzhydryl-4-(7-disubstituted amino-1,2-dihydro-3-naphthyl) methylpiperazines (16,18 and 19).

• 公益社団法人日本薬学会の論文
• 1983-06-25

著者

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 伊藤 克己

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 岡 良和

  Central Research Division, Takeda Chemical Industries, Ltd.

• 平田 稔

  Central Research Division, Takeda Chemical Industries, Ltd.

• 伊藤 克巳

  武田薬品工業

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Central Research Division, Takeda Chemical Industries, Ltd.

• 田辺 正雄

  Central Research Division, Takeda Chemical Industries, Ltd.

• 岡 良和

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 平田 稔

  Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Central Research Division Takeda Chemical Industries Ltd.

• 田辺 正雄

  Central Research Division Takeda Chemical Industries Ltd.

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