Synthesis and Glutamate-Agonistic Acitivity of (S)-2-Amino-3-(2,5-dihydro-5-oxo-3-isoxazolyl)-propanoic Acid Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
(S)-2-Amino-3-(2,5-dihydro-5-oxo-3-isoxazolyl)propanoic acid, (3a) and its analogs (3b-h) were prepared and evaluated for glutamate receptor-agonistic and antifungal activities. Several(S)-and (R)-2-amino-3-isoxazolylpropanoic acid derivatives (3a-d) were synthesized starting with (S)-and (R)-N-tert-butoxycarbonyaspartic acid α-methyl esters (4,n=1) by means of Masamune's chain extension reaction followed by isoxazolone formation with hydroxylamine and subsequent deprotection reactions. Furthermore, (S)-and (R)-N-tert-butoxycarbonylglutamic acid α-methyl esters (4,n=2) were converted to (S)- and (R)-2-amino-4-isoxazolylbutyric acid derivatives (3e-h) via the same sequence of reactions.
- 公益社団法人日本薬学会の論文
- 1992-02-25
著者
-
伊藤 克己
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
-
伊藤 克巳
武田薬品工業
-
伊藤 克已
Central Research Division Takeda Chemical Industries Ltd.
-
田村 典一
武田薬品工業(株)
-
田村 典一
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.,
-
岩間 斗史
Biology Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.,
-
伊藤 克己
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.,
-
岩間 斗史
Biology Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
関連論文
- Synthesis and Platelet-Activating Factor (PAF)-Antagonistic Activities of 1,4-Disubstituted Piperazine Derivatives
- Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of N-[(1S)-1-Carboxy-5-(4-piperidyl)pentyl]-L-alanine Derivatives
- Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. III
- Synthesis and Angiotensin converting Enzyme Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. II
- Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. I
- The Synthesis of N, N'-Disubstituted 2,5-Diamino-6-hydroxy-1,2,3,4-tetrahydro-1-naphthalenol Derivatives
- The Syntheses and β-Adrenoceptor Activities of N-Substituted 2-Amino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenols
- Optically Active Antifungal Azoles. III. Synthesis and Antifungal Activity of Sulfide and Sulfonamide Derivatives of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H, 1,2,4-triazol-1-yl)-2-butanol
- Optically Active Antifungal Azoles. I. Synthesis and Antifungal Activity of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol and Its Stereoisomers
- Synthesis and β-Adrenergic Blocking Activity of 2-(N-Substituted amino)-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives
- Synthesis of 2-(N-Substituted amino)-6-hydroxy-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives
- Syntheses of 6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Derivatives
- Studies on the Syntheses of N-Heterocyclic Compounds. XXVI. Syntheses of Pyrido [3,4-d] pyridazine Derivatives. (3)
- Studies on the Syntheses of N-Heterocyclic Compounds. XXV. Syntheses of Pyrido [3,4-d] pyridazine Derivatives. (2)
- Studies on the Syntheses of N-Heterocyclic Compounds. XXIV. Oxidation of Dihydrotetraazanaphthalene Derivatives
- Studies on the Syntheses of N-Heterocyclic Compounds. XXII. The Reaction of Polyazanaphthalene Derivatives with Organometallic Reagents
- Synthesis and Antibacterial Activity of Lactivicin Derivatives
- Synthesis of Carbapenems with a Sulfonyl Group in the C-6 Side-Chain and Their Biological Activity(Organic,Chemical)
- 96(P16) 強力な鎮痛作用を有するダフナンジテルペン、レジニフェラトキシンのエナンチオ選択的全合成(ポスター発表の部)
- Syntheses of 1,2-N-Alkylimino-1,2,3,4-tetrahydronaphthalene Derivatives and Preparation of Ring Closed Analog of Salbutamol as a New β-Adrenoceptor Agent
- Synthesis and Human Immunodeficiency Virus (HIV)-1 Protease Inhibitory Activity of Tripeptide Analogues Containing a Dioxoethylene Moiety
- Synthesis and Biological Activity of (S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic Acid (TAN-950 A) Derivatives
- Optically Active Antifungal Azoles. V. Synthesis and Antifungal Activity of Stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols
- Optically Active Antifungal Azoles. IV. Synthesis and Antifungal Activity of (2R, 3R)-3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols
- Optically Active Antifungal Azoles. II. Synthesis and Antifungal Activity of Polysulfide Derivatives of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol
- Syntheses of conformationally Rigid Catecholamine Derivatives
- 含窒素複素環式化合物の合成研究(第19報)4-Alkyl-5,8-disubstituted Amino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazineの合成
- Synthesis and Glutamate-Agonistic Acitivity of (S)-2-Amino-3-(2,5-dihydro-5-oxo-3-isoxazolyl)-propanoic Acid Derivatives
- Synthesis and Biological Activities of 3-Aminomethyl-1,2-dihydronaphthalene Derivatives
- Design and Synthesis of N-[N-[(S)-1-Ethoxycarbonyl-3-phenylprolyl]-L-alanyl]-N-(indan-2-yl)glycine (CV-3317), a New, Potent Angiotensin Converting Enzyme Inhibitor
- Synthesis of 3-Aryl-6-aminocyclohex-2-enol Derivatives
- The Synthesis of 7,8-Dihydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-1-ol
- An Improved Synthesis of the New Angiotensin Converting Enzyme Inhibitor CV-5975 via a Chemoenzymatic Process(Organic,Chemical)