Synthesis and β-Adrenergic Blocking Activity of 2-(N-Substituted amino)-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• In a search for a new structural type of β-adrenergic antagonist. a series of trans-2-(N-substituted amino)-1,2,3,4-tetrahydronaphthalen-1-ol derivatives (3-36) was synthesized in several steps from 3,4-dihydro-1 (2H)-naphthalenone (37) having a variety of substituents at the 5-, 6-, 7-and 8-positions. Compounds 3-36 were tested in vitro for β-adrenergic activity. Among them, 2-benzhydrylamino-6-chloro-1,2,3,4-tetrahydronaphthalen-1-ol (28c) was found to show a fairly potent β-adrenergic blocking activity.

• 公益社団法人日本薬学会の論文
• 1984-01-25

著者

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 伊藤 克己

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 岡 良和

  Central Research Division, Takeda Chemical Industries, Ltd.

• 平田 稔

  Central Research Division, Takeda Chemical Industries, Ltd.

• 伊藤 克巳

  武田薬品工業

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Central Research Division, Takeda Chemical Industries, Ltd.

• 多田 憲生

  Central Research Division, Takeda Chemical Industries, Ltd.

• 多田 憲生

  Central Research Division Takeda Chemical Industries Ltd.

• 岡 良和

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 平田 稔

  Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Central Research Division Takeda Chemical Industries Ltd.

関連論文

• Synthesis and Platelet-Activating Factor (PAF)-Antagonistic Activities of 1,4-Disubstituted Piperazine Derivatives
• Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of N-[(1S)-1-Carboxy-5-(4-piperidyl)pentyl]-L-alanine Derivatives
• Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. III
• Synthesis and Angiotensin converting Enzyme Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. II
• Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1,5-Benzothiazepine and 1,5-Benzoxazepine Derivatives. I
• Structure-Activity Study of Diuretic Azanaphthalene Derivatives
• Structure-Activity Relationships of the Diuretic Activity of Triaza- and Tetraaza-naphthalene Compounds
• 1,5-Benzoxathiepin Derivatives. II. Synthesis and Serotonin S_2-Receptor-BIocking Activity of Aminoalkyl-Substituted 3,4-Dihydro-2H-1,5-benzoxathiepin-3-ols and Related Compounds(Medicinal Chemistry,Chemical)
• The Synthesis of N, N'-Disubstituted 2,5-Diamino-6-hydroxy-1,2,3,4-tetrahydro-1-naphthalenol Derivatives
• The Synthesis of 2,5-Diamino-6-hydroxy-1,2,3,4-tetrahydro-1-naphthalenol Derivatives
• The Syntheses and β-Adrenoceptor Activities of N-Substituted 2-Amino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenols
• Optically Active Antifungal Azoles. III. Synthesis and Antifungal Activity of Sulfide and Sulfonamide Derivatives of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H, 1,2,4-triazol-1-yl)-2-butanol
• Optically Active Antifungal Azoles. I. Synthesis and Antifungal Activity of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol and Its Stereoisomers
• Synthesis and β-Adrenergic Blocking Activity of 2-(N-Substituted amino)-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives
• Synthesis of 2-(N-Substituted amino)-6-hydroxy-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives
• 4位置換イソクロマン誘導体の合成
• 4位置換1,2,3,4-テトラヒドロイソキノリン誘導体の合成
• Syntheses of 6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Derivatives
• Studies on the Syntheses of N-Heterocyclic Compounds. XXVIII. Syntheses of Pyrido [3,4-d] pyridazine Derivatives. (4)
• Studies on the Syntheses of N-Heterocyclic Compounds. XXVI. Syntheses of Pyrido [3,4-d] pyridazine Derivatives. (3)
• Studies on the Syntheses of N-Heterocyclic Compounds. XXV. Syntheses of Pyrido [3,4-d] pyridazine Derivatives. (2)
• Studies on the Syntheses of N-Heterocyclic Compounds. XXIV. Oxidation of Dihydrotetraazanaphthalene Derivatives
• Studies on the Syntheses of N-Heterocyclic Compounds. XXII. The Reaction of Polyazanaphthalene Derivatives with Organometallic Reagents
• Syntheses of 1,2-N-Alkylimino-1,2,3,4-tetrahydronaphthalene Derivatives and Preparation of Ring Closed Analog of Salbutamol as a New β-Adrenoceptor Agent
• Synthesis and Human Immunodeficiency Virus (HIV)-1 Protease Inhibitory Activity of Tripeptide Analogues Containing a Dioxoethylene Moiety
• Studies on the Syntheses of N-Heterocyclic Compounds. IV. Hypocholesterolemic 1,2,4-Oxadiazole Derivatives. (2)
• Studies on the Synthese of N-Heterocyclic Compounds. III. Hypocholesterolemic 1,2,4-Oxadiazole Derivatives (1)
• Optically Active Antifungal Azoles. V. Synthesis and Antifungal Activity of Stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols
• Optically Active Antifungal Azoles. IV. Synthesis and Antifungal Activity of (2R, 3R)-3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols
• Optically Active Antifungal Azoles. II. Synthesis and Antifungal Activity of Polysulfide Derivatives of (2R, 3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol
• Syntheses of conformationally Rigid Catecholamine Derivatives
• Studies on the Syntheses of N-Heterocyclic Compounds. XXIII. The Photochemical Reaction of Polyazanaphthalene Derivatives
• 含窒素複素環式化合物の合成研究(第19報)4-Alkyl-5,8-disubstituted Amino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazineの合成
• 含窒素複素環式化合物の合成研究(第14報)7-Phenyl-s-triazolo-[4,3-α]pyridine誘導体の合成
• Synthesis and Glutamate-Agonistic Acitivity of (S)-2-Amino-3-(2,5-dihydro-5-oxo-3-isoxazolyl)-propanoic Acid Derivatives
• Stereoselective Syntheses of cis- and trans-2-Alkylamino-1,2,3,4-tetrahydro-1-naphthalenols by Acid-catalyzed Ring Opening of 1,2-N-Alkylimino-1,2,3,4-tetrahydronaphthalenes
• Synthesis and Biological Activities of 3-Aminomethyl-1,2-dihydronaphthalene Derivatives
• 高血圧自然発症(SHR)ラットにおけるAdriamycin投与時の心電図異常と心筋エネルギ-代謝変化に及ぼす2,3-Dimethoxy-5-methyl-6-(10′-hydroxydecyl)-1,4-benzoquinone(CV-2619)の影響
• ラット赤血球の解糖系に及ぼす2,3-Dimethoxy-5-methyl-6-(10′-hydroxydecyl)-1,4-benzoquinone(CV-2619)の影響
• Design and Synthesis of N-[N-[(S)-1-Ethoxycarbonyl-3-phenylprolyl]-L-alanyl]-N-(indan-2-yl)glycine (CV-3317), a New, Potent Angiotensin Converting Enzyme Inhibitor
• Synthesis of 3-Aryl-6-aminocyclohex-2-enol Derivatives
• 医薬品化学におけるコンピュ-タの利用
• The Synthesis of 7,8-Dihydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-1-ol
• An Improved Synthesis of the New Angiotensin Converting Enzyme Inhibitor CV-5975 via a Chemoenzymatic Process(Organic,Chemical)
• ラット赤血球の解糖系に及ぼす2，3-Dimethoxy-5-methyl-6-(10-hydroxydecyl)-1，4-benzoquinone(CV-2619)の影響
• 高血圧自然発症(SHR)ラットにおけるAdriamycin投与時の心電図異常と心筋エネルギー代謝変化に及ぼす2，3-Dimethoxy-5-methyl-6-(10-hydroxydecyl)-1，4-benzoquinone(CV-2619)の影響
• 1位置換イソクロマン及びイソチオクロマン誘導体の合成

もっと見る 閉じる

スポンサーリンク