Structure-Activity Relationships of the Diuretic Activity of Triaza- and Tetraaza-naphthalene Compounds

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概要

• 論文の詳細を見る

• The diuretic activity of 219 nitrogen containing heterocyclic compounds, classified into 13 groups based on the structural features, was studied on the saline loaded rats. One hundred and four out of the 219 compounds were active at the oral doses of 10 to 30 mg/kg. Several of pyrimidopyridazines, pyridazinopyridazines and pyridopyridazines produced as potent diuresis and natriuresis as hydrochlorothiazide at the oral dose of 0.1 mg/kg, in which 2-phenyl-5,8-dimorpholinopyrimido [4,5-d]-pyridazine (DS-210) and 1,4-dimorpholino-7-phenylpyrido [3,4-d] pyridazine (DS-511) were selected for more extensive evaluation as diuretic agents. Structure-activity relationships of the tested compounds are discussed.

• 社団法人日本薬学会の論文
• 1976-09-25

著者

• 西川 浩平

  日本製薬株式会社研究本部

• 西川 浩平

  Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries

• 稲田 義行

  武田薬品工業株式会社研究推進部

• 柴生田 由美子

  Biology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.,

• 西川 浩平

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 嶋川 久男

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 稲田 義行

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 柴生田 由美子

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 菊地 慎太郎

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 万木 庄次郎

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 岡 良和

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 万木 庄次郎

  武田薬品中研

• 稲田 義行

  武田薬品工業株式会社 医療開拓研究本部

• 岡 良和

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 嶋川 久男

  Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 菊地 慎太郎

  Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 柴生田 由美子

  Biology Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

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