Synthesis and Reaction of 1-(N, N-Disubstituted amino) pyrazoles

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概要

• 論文の詳細を見る

• Some 1-(N, N-disubstituted amino) pyrazoles were synthesized by 1,3-dipolar cyclo-addition of 3-(N, N-disubstituted amino) sydnones with acetylenes. Arylacetylenes gave 3-arylpyrazoles preferentially. The structures were determined by ultraviolet and nuclear magnetic resonance spectroscopy, and further confirmed by catalytic hydrogenolysis and mass spectroscopy. Nitration and halogenation of 3-phenyl-1-aminopyrazoles occurred smoothly at C-4 first and at C-5 subsequently.

• 社団法人日本薬学会の論文
• 1976-12-25

著者

• 岸本 彰二

  Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.

• 野口 俊作

  Central Research Division, Takeda Chemical Industries, Ltd.

• 増田 克忠

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division Takeda Chemical Industries Ltd.

• 岸本 彰二

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 増田 克忠

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

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