Studies on Azetidine Derivatives. II. Reactions and Stereochemistry of 3-Substituted 1-Cyclohexyl-2-phenylazetidines
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概要
- 論文の詳細を見る
The stereochemical course of diastereomeric 1-cyclohexyl-2-phenyl-3-azetidinyl mesylates (IVa and Va) was investigated with nucleophilic reagents. The retention of the configuration in these reactions and ring contracted products in some cases of reactions of IVa were observed. The presence of 1-azabicyclobutonium ions (VII and VIII) as intermediates in these reactions has been proposed from these results. The stereochemistry of 3-substituted azetidines obtained by nucleophilic reactions via IVa and Va was established by chemical evidence and nuclear magnetic resonance studies with a shift reagent, Eu (DPM)_3.
- 社団法人日本薬学会の論文
- 1974-07-25
著者
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増田 克忠
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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増田 克忠
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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奥谷 哲也
Chemical Research laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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奥谷 哲也
Central Research Division Takeda Chemical Industries Ltd.
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