Studies on Azetidine Derivatives. I. Synthesis of 3-Substituted Azetidine Derivatives
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概要
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In order to find pharmacologically active azetidine derivatives, convenient procedures for the synthesis of 3-substituted azetidines have been investigated. 3-Azetidinyl mesylates (IV), prepared by treatment of azetidin-3-ols (I) with sulfenes, were shown to be useful intermediates for the synthesis of 3-substituted azetidines, 3-amino-, 3-cyano-, 3-guanidinoazetidines (V, VI and VIII) and azetidine-3-carboxylic acids (VII) via VI. 1-Cyclohexyl-3-guanidinoazetidine showed an excellent antihypertensive activity.
- 社団法人日本薬学会の論文
- 1974-07-25
著者
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増田 克忠
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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増田 克忠
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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奥谷 哲也
Chemical Research laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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金児 龍彦
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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奥谷 哲也
Central Research Division Takeda Chemical Industries Ltd.
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金児 龍彦
Research and Development Division, Takeda Chemical Industries, Ltd.,
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金児 龍彦
Research And Development Division Takeda Chemical Industries Ltd.
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