Synthesis and Antitumor Activity of 5-Fluoro-4-(furfurylidene aminooxy)hexahydro-2,6-dioxo-5-pyrimidinecarboxylates

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概要

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• A series of 5-fluoro-t-4-[(Z)- and (E)-furfurylideneaminooxy]hexahydro-2,6-dioxor-5-pyrimidinecarboxylates (6 and 7) was prepared by treatment of the corresponding 4-acetoxyhexa-hydropyrimidinecarboxylates 5 with (Z)- and (E)-furfuraldoximes (10 and 11), respectively, and tested for antitumor activity against murine colon carcinoma 26. The oxime ether 7c (TAC-788) showed antitumor activity against various murine tumors.

• 社団法人日本薬学会の論文
• 1986-02-25

著者

• 山本 弘昭

  Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires

• 鵜川 清

  Central Research Division, Takeda Chemical Ind., Ltd.,

• 山本 弘昭

  Central Research Division, Takeda Chemical Ind., Ltd.,

• 奥谷 哲也

  Central Research Division, Takeda Chemical Ind., Ltd.,

• 野村 容朗

  Central Research Division, Takeda Chemical Ind., Ltd.,

• 天野 利夫

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 大津 紘一郎

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 香西 義雄

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 香西 義雄

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 天野 利夫

  Biochemical Research Institute, Nippon Menard Cosmetic Co., Ltd.

• 野村 容朗

  Research and Development Division, Eisai Company, Ltd.,

• 奥谷 哲也

  Resarch & Development Division Takeda Chemical Industries Ltd.

• 奥谷 哲也

  Central Research Division Takeda Chemical Industries Ltd.

• 野村 容朗

  Research And Development Division Eisai Company Ltd.

• 鵜川 清

  Resarch & Development Division Takeda Chemical Industries Ltd.

• Nomura Hiroaki

  Research And Development Division Eisai Company Ltd.

• 大津 紘一郎

  Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.

• 天野 利夫

  Biochemical Research Institute Nippon Menard Cosmetic Co. Ltd.

• Yamamoto Hiroaki

  Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries

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