Cyanine Dyes, New Potent Antitumor Agents
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概要
- 論文の詳細を見る
Antitumor agents of a new structural type are reported. A number of cyanines with mono-, di- and tricyclic nuclei, merocyanines and oxonols have been i. p. screened for antitumor activity against P388 leukemia and B16 melanoma. Among these compounds, monomethin-, trimethin- and pentamethincyanines having naphthothiazole, naphthoxazole and benzindole nuclei resulted in a significant prolongation of the survival time of tumor-bearing mice. Replacement of the conjugated chain system between the terminal two nuclei with a saturated aliphatic chain produced a marked decrease in the antitumor activity. Structure-activity relationships are discussed.
- 社団法人日本薬学会の論文
- 1982-09-25
著者
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田代 田鶴子
Division of Experimental Chemotherapy Cancer Chemotherapy Center
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南 功
Central Research Division Takeda Chemical Industries Ltd.
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野村 容朗
Central Research Division, Takeda Chemical Ind., Ltd.,
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香西 義雄
Central Research Division, Takeda Chemical Industries, Ltd.,
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香西 義雄
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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野村 容朗
Research and Development Division, Eisai Company, Ltd.,
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野村 容朗
Research And Development Division Eisai Company Ltd.
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Nomura Hiroaki
Research And Development Division Eisai Company Ltd.
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