Purification and Characterization of Mouse α_1-Acid Glycoprotein and Its Possible Role in the Antitumor Activity of Some Lichin Polysaccharides
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概要
- 論文の詳細を見る
Administration of some anititumor lichen polysaccharides (ALP) increased the serum level of α_1-acid glycoproteins (α_1-AG) in mice, possibly as a result of liver cell necrosis or inflammation induced by those polysaccharides.Ascites tumor-bearing mice were treated with ALP, and ascitic fluid having a high α_1-AG level was harvested. Mouse α_1-AG was obtained from this source in quanity, and fractionated into α_1-AG-1 and -2.The time courses of the serum level of α_1-AG and of the growth of subcutaneously implanted tumor were found to correlate well in ALP-treated mice, and purified α_1-AG-1 inhibited the growth of tumor cells in vitro at a concentration normally observed in animals with inflammation. These results suggest that α_1-AG plays a significant role in the antitumor activity exhibited by ALP.
- 社団法人日本薬学会の論文
- 1986-06-25
著者
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柴田 承二
Meiji College of Pharmacy
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高橋 邦夫
Meiji College of Pharmacy
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高橋 邦夫
明治薬科大学
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田代 田鶴子
Cancer Chemotherapy Center
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田代 田鶴子
Division of Experimental Chemotherapy Cancer Chemotherapy Center
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柴田 承二
Shibata Laboratory Of Natural Medicinal Materials C
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成井 孝雄
Meiji College of Pharmacy
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渡辺 素子
Research Institute of Tuberculosis
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岩井 和郎
Research Institute of Tuberculosis
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Shibata Shoji
Shibata Laboratory Of Natural Medicinal Materials C/o Minophagen Pharmaceutical Co.
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成井 孝雄
Department Of Microbiology Fukushima Medical College:c
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