菌類代謝産物の研究(第5報)Skyrinの構造についてその1

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The structure of skyrin and its reductive cleavage with Na_2S_2O_4 giving emodin were discussed using some model compounds, 4,4'-dihydroxy-, 2,2'-dihydroxy-, and 2,2'-dimethoxy-4,4'-dihydroxy-bianthraquinones-(1,1'). The latter two compounds were subjected to the cleavage reaction with Na_2S_2O_4. Dimethyl ether of skyrin prepared by the action of methanol and conc. H_2SO_4 was proved to be different from dimethyl ether prepared with diazomethane, the latter yielded physcion by reductive cleavage. It was considered that the latter is a genuine dimethyl ether of skyrin while an isomerized form was suggested for the former compound designating pseudoskyrin dimethyl ether. A formula, 2,4,5,2', 4', 5'-hexahydroxy-7,7'-dimethylbianthraquinone-(1,1') was proposed for skyrin.
公益社団法人日本薬学会の論文
1955-08-20