菌類代謝産物の研究(第8報)Rugulosinその1 Dianhydrorugulosinの構造とIridoskyrinの構造との関係

概要

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i) Dianhydrorugulosin, C_<30>H_<18>O_8,which was derived from rugulosin, C_<30>H_<22>O_<10>, a pigment of P.rugulosum Thom, by a dehydrationreaction, was converted into bisnordianhydrorugulosin which was synthetically proved to be identical with 4,5,4', 5'-tetrahydroxybianthraquinone-(1,1'). ii) Iridoskyrin, C_<30>H_<18>O_<10>, a pigment of P.islandicum Sopp, yielded islandicin (1,4,5-trihydroxy-2-methylanthraquinone) by reductive cleavage with alkaline Na_2S_2O_4. Dianhydrorugulosin gave chrysophanol by the same reaction. iii) Dianhydrorugulosin was derived from iridoskyrin by the action of HI and red phosphorus, then with CrO_3,losing two hydroxyls. iv) By the above reactions, the structure of dianhydrorugulosin was established as being 4,5,4', 5'-tetrahydroxy-7,7'-dimethylbianthraquinone-(1,1'), while iridoskyrin was proved conversely to be 4,5,8,4', 5', 8'-hexahydroxy-7,7'-dimethylbianthraquinone-(1,1'). v) A fundamental skeleton of rugulosin has been forwarded.
社団法人日本薬学会の論文
1956-04-20