Antitumor Activity of Shikonin and Its Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Shikonin, a naphthoquinone contained in the root of Lithospermum officinalis var. erythrorhizon MAX. and Macrotomia euchroma (ROYLE) PAULS (Boraginaceae), showed a high antitumor activity against the ascites cells of Sarcoma 180. Shikonin completely inhibited the tumor growth at a dose of 5-10 (mg/kg/day). At a higher dose (>15 mg/kg/day) shikonin showed'toxicity, whereas at a lower dose (1 mg/kg/day) it was inactive. Four shikonin derivatives and the chromatographic fractions of the plant extracts were also tested and they showed similar antitumor activities against S-180.
- 公益社団法人日本薬学会の論文
- 1977-09-25
著者
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柴田 承二
Faculty of Pharmaceutical Sciences, University of Tokyo
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柴田 承二
東大・薬
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猪俣 素子
国立がんセンター研究所
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猪俣 素子
国立がんセ・研・薬効試験
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猪俣 素子
国立がんセンター研究所薬効試験部
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柴田 承二
柴田天然薬物研究室
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福岡 文子
National Cancer Center Research Institute
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柴田 承二
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)meiji College Of Pharmacy
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大塚 英昭
Faculty Of Pharmaceutical Sciences University Of Tokyo
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柴田 承二
明治薬科大学
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柴田 承二
Faculty Of Pharmaceutical Sciences University Of Tokyo
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磯村 八州男
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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磯村 八州男
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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