Synthesis and Antitumor Activity of Riboflavin and Flavin Mononucleotide Pt(II) Complexes

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概要

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• Several Pt(II) complexes of riboflavin (RF) and flavin mononucleotide (FMN) with 1,2-cyclohexanediamine (dach) or 2-(aminomethyl)cyclohexylamine (amcha) isomers were prepared. The coordination sites of RF or FMN to Pt(II) ions were determined to be N(5) and O(6) with resultant chelate ring formation.Antitumor activities of the dach or amcha Pt(II) complexes were tested against murine leukemia L1210 and all of them were antitumor-active. Pt(FMN)(trans-l-dach) exhibited the higher activity with a T/C% value of 326,with 4 cured mice out of 6. These results justify further testing.

• 公益社団法人日本薬学会の論文
• 1988-05-25

著者

• 喜谷 喜徳

  Faculty of Pharmaceutical Sciences Nagoya City University

• 田代 田鶴子

  Division of Experimental Chemotherapy Cancer Chemotherapy Center

• 鈴木 憲治郎

  Department of Pharmacy, Tokai Teishin Hospital

• 喜谷 喜徳

  名古屋市立大学薬学部

• 鈴木 憲治郎

  Department Of Pharmacy Tokai Teishin Hospital

• 野路 雅英

  名古屋市大 薬

• 野路 雅英

  Japan, Faculty of Pharmaceutical Sciences, Nagoya City University

• 田代 田鶴子

  Japan and Cancer Chemotherapy Center, Japanese Foundation for Cancer Research

• 喜谷 喜徳

  Japan, Faculty of Pharmaceutical Sciences, Nagoya City University

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