Cytotoxicity of Platinum(IV) and Platinum(II) Complexes Containing 1R, 2R-Cyclohexanediamine as a Ligand
スポンサーリンク
概要
- 論文の詳細を見る
Several Pt(IV) and Pt(II) complexes containing 1R, 2R-cyclohexanediamine (1R, 2R-dach) as a carrier ligand were synthesized. The cytotoxicities and the uptake of the platinum complexes by leukemia L1210 cells were compared in order to study the correlation between their structures and cytotoxicities.[Pt(II)Cl_2(1R, 2R-dach)], [(Pt(II)(oxalato)(1R, 2R, -dach)], and [Pt(II)(malonato)(1R, 2R-dach)], which have excellent anticancer properties, exhibited very high cytotoxicities and were easily taken up by leukemia L1210 cells. [Pt(IV)Cl_4(1R, 2R-dach)], trans(Cl)-[Pt(IV)Cl_2(oxalato)(1R, 2R-dach)], and trans(Cl)-[Pt(IV)Cl_2(malonato)(1R, 2R-dach)] also had high cytotoxicities. After a short incubation time, the uptake of [Pt(II)Cl_2(1R, 2R-dach)], [Pt(II)(oxalato)(1R, 2R-dach)], and [Pt(II)(malonato)(1R, 2R-dach)] by leukemia L1210 cells were respectively very similar to those of [Pt(IV)Cl_4(1R, 2R-dach)], trans(Cl)-[Pt(IV)Cl_2(oxalato)(1R, 2R-dach)], and trans(Cl)-[Pt(IV)Cl_2(malonato)(1R, 2R-dach)].In addition, trans(OH)-[Pt(IV)(OH)_2Y_2(1R, 2R-dach)] (Y_2 : oxalato or malonato) did not exhibit cytotoxicity towards leukemia L1210 cells, whereas trans(Cl)-[Pt(IV)Cl_2Y_2(1R, 2R-dach)] (Y_2 : oxalato or malonato) were highly cytotoxic. The accumulation of trans(OH)-[Pt(IV)(OH)_2Y_2(1R, 2R-dach)] in leukemia L1210 cells was much lower than that of trans(Cl)-[Pt(IV)Cl_2Y_2(1R, 2R-dach)]. Platinum(IV) complexes, in which leaving groups are replaced by hydroxide groups, have decreased cytotoxic activity, because the hydroxide groups of the platinum(IV) complex reduce the uptake of platinum by the cells. trans(OH), cis(Cl)-[Pt(IV)(OH)_2Cl_2(1R, 2R-dach)], which has hydroxide and chloride groups, was easily incorporated into the cells and exhibited the high cytotoxic activity. This behavior indicates that the chloride group apparently overcomes the ameliorating effect of the hydroxide group.
- 社団法人日本薬学会の論文
- 1993-10-15
著者
-
喜谷 喜徳
Faculty of Pharmaceutical Sciences Nagoya City University
-
富田 久夫
福山大学
-
山下 朋子
名古屋市立大学薬学部
-
斉藤 玲子
愛知看護短期大学
-
山下 朋子
Faculty of Pharmaceutical Sciences, Nagoya City University
-
廣瀬 順造
Department of Food Science and Technology, Faculty of Engineering, Fukuyama University
-
野路 雅英
Faculty of Pharmaceutical Sciences, Nagoya City University
-
斉藤 玲子
Aichi Junior College of Nursing
-
富田 久夫
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
-
廣瀬 順造
Department Of Food Science And Technology Faculty Of Engineering Fukuyama University
-
喜谷 喜徳
名古屋市立大学薬学部
-
野路 雅英
Faculty Of Pharmaceutical Sciences Nagoya City University
-
野路 雅英
名古屋市大 薬
関連論文
- Antineoplastic Activity of Platinum Complexes of trans-(dl)-1,2-Cyclopentanediamine
- キトサンの可逆的ゲルーゲル転移を利用した薬物の放出制御(発表論文抄録(2003))
- キトサンの可逆的ゲル-ゲル転移を利用した薬物の放出制御
- 1R,2R-シクロヘキサンジアミンを配位子にもつ四価および二価白金錯体の細胞毒性(発表論文抄録(1993))
- Cytotoxicity of Platinum(IV) and Platinum(II) Complexes Containing 1R, 2R-Cyclohexanediamine as a Ligand
- Syntheses and Antitumor Activities of 1R,2R-Cyclohexanediamine Pt(II) Complexes Containing Dicarboxylates(Medicinal Chemistry,Chemical)
- 酸性溶液中でのフェノチアジン系トランキライザーのラウロマクロゴールミセルへの取り込み(発表論文抄録(1984年),福山大学開学10周年記念号)
- Uptake of Phenothiazine Tranquilizers by Lauromacrogol Micelles in Acidic Solution
- 溶媒抽出,原子吸光光度法によるヒスタミンの選択的定量
- Preparation and Complex Formation of Cyclic Octapeptides Containing L-Proline Residues with Phenylalanine Methylester Hydrochloride
- Zinc Deficient Bovine Erythrocyte Superoxide Dismutase Has Low Specific Activity
- 白金ホスフィン錯体のラマンスペクトル
- 枯草菌芽胞の発芽に対するフェノール類および脂肪酸類の定量的構造発芽阻止活性相関
- Solubilization of Steroid Hormones by Polyoxyethylene Lauryl Ether
- Solubilization of Benzoic Acid Derivatives by Polyoxyethylene Lauryl Ether
- Effect of Micellar Interactions on Base-Catalyzed Hydrolysis of Procaine
- Micellar Interaction of Tetracycline Antibiotics
- The Crystal Structure and Absolute Configuration of the Antitumor Platinum Complex tran(OH)-Pt(OH)_2(Malonato)(1R, 2R, -Cyclohexanediamine)
- Studies on Synthesis, Structure, and Antitumor Activity of Pt(II) Complexes Containing 1,2-Diamino-1,2-dideoxy-D-glucitol
- The Measurement of cis-Platin and trans-Platin by Graphite Atomic Absorption Spectrophotometry
- Studies of Copper-Binding Behavior of Copper-Free and Apo-superoxide Dismutase by High-Performance Liquid Chromatography
- Magnetic Circular Dichroic Spectra of Various Adducts of Co (II)-Bovine Carbonic Anhydrase
- Coordination Chemical Studies on Metalloenzymes. VIII. Reduction of Co (III)-Bovine Carbonic Anhydrase with L-Ascorbic Acid
- Coordination Chemical Studies on Metalloenzymes. IV. Kinetic and Thermodynamic Studies of Metal Removal Reaction from Zinc-and Cobalt-Carbonic Anhydrase with Chelating Agents
- 過剰な亜鉛イオンによるカルボキシペプチダ-ゼAの活性阻害作用--タンパク質の立体構造変化の可能性 (生体関連物質と配位化学) -- (金属酵素・金属タンパク質)
- 各種キレ-ト化剤による炭酸脱水酵素からの金属除去反応に対するpHと活性阻害剤の影響
- 高速液体クロマトグラフィ-によるCr(3)の定量
- Studies on Mass Spectrometry of Metal Chelates. II. Mass Spectrometric Investigation of Thiooxine Metal Chelates
- 白金錯体の制がん効果--最近の話題
- 制癌作用を有する白金錯体の化学 (金属と薬理活性)
- 医薬品としての金属錯体"プラチナががんをなおす" (有機金属錯体--広がるその領域)
- 金属含有医薬品開発の現況 (微量元素と生物圏)
- 1,2-シクロヘキサンジアミンおよび2-(アミノメチル)シクロヘキシルアミン異性体の白金(4)錯体の制がん性と性質 (生体関連物質と配位化学) -- (生理・薬理活性)
- Platinum and Palladium Complexes Containing Ethylenediamine Derivatives as Carrier Ligands and Their Antitumor Activity
- Synthesis and Antitumor Activity of Pt (II) Complexes containing 2,3-Diaminopropanol Isomers
- Synthesis of Pt(II) Complexes Containing D-Glucuronate, D-Gluconate, or Their Acetyl Derivatives and Evaluation of Antitumor Activity against Murine Leukemia L1210
- Synthesis and Antitumor Activity of Riboflavin and Flavin Mononucleotide Pt(II) Complexes
- Antitumor Activity of Pt(II) Complexes Containing Diaminocarboxylates and Their Ester Derivatives
- Platinum Complexes of Diaminocarboxylates and Their Ethyl Ester Derivatives : Antitumor Activity and Interaction with Deoxyribonucleic Acid
- Cytotoxicity of Asymmetric Platinum Complexes against L-1210 Cells. Effect of Bulky Substituents
- オランダからの留学生(薬系大学における国際交流 : 海外からの留学生受け入れ)
- 高速液体クロマトグラフィ-による抗がん活性白金錯体とDNAおよび核酸塩基との相互作用に関する研究 (最新の化学分離法) -- (クロマトグラフィ-)
- STERIC EFFECT IN BINDING OF ANTITUMOR ACTIVE PLATINUM (II) COMPLEX TO NUCLEIC ACID BASE
- 制癌性白金錯体の研究
- Direct Determination of cis-Dichlorodiammineplatinum (II) in Urine by Derivative Spectroscopy
- 第9回毒物コントロールセンター欧洲連合国際会議, 国際裁判化学毒物者欧洲会議および第8回国際微量化学シンポジウム
- Studies on the Metal Chelate Compounds of Phenazine Derivatives. XI. Metal Chelates of 1-Phenazinethiol
- Studies on the Metal Chelate Compounds of Phenazine Derivatives. IX. : Formation Constants of Metal Chelates of Hydroxybenzo [a]-phenazine Derivatives
- Studies on the Mixed-Ligand Complexes. III. Mixed-Ligand Complexes between Alloxan and Glycine with Bivalent Metals
- Studies on the Mixed-Ligand Complexes. II. Synthesis of the Mixed-Ligand Complexes between 8-Hydroxyquinoline-5-sulfonic Acid and L-Histidine with Metals
- Studies on the Mixed Ligand Complexes. I. Synthesis of Glycine Oxine Cobalt (III) Complex
- Synthesis of 1-(Methylthio) phenazine Platinum (II) and Its S-demethylated Complexes
- 金属錯体化学からみた発癌と制癌
- Studies on the Metal Chelate Compounds of Phenazine Derivatives. XII. Far-infrared Spectra of the Metal Chelates of Hydroxyphenazine Derivatives
- 癌と白金錯体--第3世代抗癌性白金錯体の開発 (微量金属の生体作用--金属イオンの生理機能と薬理作用解明をめざして) -- (疾患と微量金属)
- 制がん作用をもった白金錯体 (金属イオンの生物活性--生物無機化学の新しい流れ)
- Preparation of Platinum (II) Complexes of Diamine Isomers [PtX (1,3-Diamine)] (X=Cl_2,SO_4,(NO_3)_2,Oxalato, D-Glucuronato, and D-Gluconato) and Determination of Their Antitumor Activity against Leukemia L1210
- Antitumor Activity of Platinum(2) Complexes of 1,2-Diamino-Cyclohexane Isomers
- Synthesis of Platinum (II) Complexes of 4-Substituted o-Phenylenediamine Derivatives and Determination of Their Antitumor Activity
- エチレジアミンおよびジカルボン酸イオンを含む混合配位子銅(2)錯体の分光光度法による平衡定数の測定
- 白金錯体の合成と抗腫瘍活性
- 制がん作用を有する白金錯体
- 2-アミノ-3-キノキサリンチオール誘導体によるニッケルおよびコバルトの吸光光度定量