The Crystal Structure and Absolute Configuration of the Antitumor Platinum Complex tran(OH)-Pt(OH)_2(Malonato)(1R, 2R, -Cyclohexanediamine)

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概要

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• The absolute configuration of the anti-tumor complex trans(OH)-Pt(OH)_2(malonato)(1R, 2R-cyclohexanediamine) was determined by X-ray anomalous scattering technique. The final unit cell was monoclinic, space group P2_1 with a = 9.142Å, b = 7.788Å, c = 11.946Å, β = 96.48°, Z = 2. The crystal structure was determined by direct method and difference Fourier synthesis, and refined to R = 0.025 and R_w = 0.033 based on 2768 independent reflections. The platinum atom has roughly octahedral coordination. The cyclohexane ring has the expected chair configuration, with two amino groups in equatorial positions while the malonato ligand, in contrast, shows a boat conformation for six membered Pt O-C-C-C-O ring.

• 公益社団法人日本薬学会の論文
• 1992-04-25

著者

• 喜谷 喜徳

  Faculty of Pharmaceutical Sciences Nagoya City University

• 後藤 正文

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 斉藤 玲子

  愛知看護短期大学

• 野路 雅英

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 廣瀬 順造

  Department Of Food Science And Technology Faculty Of Engineering Fukuyama University

• 後藤 正文

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 廣瀬 順造

  Food Sciences and Technology, Faculty of Engineering , Fukuyama, University

• LEE Keun-Im

  Department of Pharmacy, Graduate School, Sookmyung Women's University

• 喜谷 善徳

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 喜谷 喜徳

  名古屋市立大学薬学部

• 野路 雅英

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Lee K‐i

  Sookmyung Women's Univ. Seoul Kor

• Lee Keun-im

  Department Of Pharmacy Graduate School Sookmyung Women's University

• Lee Keun-Im

  Department of Manufacturing Pharmacy, College of Pharmacy, Sookmyung Women's University

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